Abstract
Background: Four cardiac hormones have anticancer effects in vitro: i) atrial natriuretic peptide (ANP), ii) vessel dilator, iii) long acting natriuretic peptide (LANP), and iv) kaliuretic peptide. Materials and Methods: These cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min-1 kg-1 body weight in athymic mice bearing human pancreatic adenocarcinomas. Results: ANP, vessel dilator, LANP and kaliuretic peptide eliminated 80%, 33%, 20% and 14% of the pancreatic adenocarcinomas. Even in the treated animals which did not have a total cure, their tumor volume decreased to less than 10% (and with vessel dilator to 2%) of that of the untreated animals. The natriuretic peptide receptor (NPR)-A receptor was decreased 33% to 55% in the metastatic lesions compared to the primary pancreatic adenocarcinoma. Conclusion: Four cardiac hormones eliminated up to 80% of human pancreatic adenocarcinomas in athymic mice.
Footnotes
- Received January 26, 2007.
- Accepted February 5, 2007.
- Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved