cdc25 M-phase Inducer
This extract was created in the absence of an abstract.
Excerpt
The molecular events that bring about the initiation of mitosis have been the subject of intensive investigation in recent years. Significant advances have been achieved from the convergence of three independent avenues of investigation: genetic and molecular studies of cell cycle control mutants in yeast; identification of proteins whose levels or activities oscillate during the cell cycle and peak at mitosis; and biochemical analysis of proteins that trigger mitotic events when injected into animal oocytes or added to extracts thereof. These studies have recently been reviewed by Murray and Kirschner (1989) and Nurse (1990). They have established that the initiation of mitosis is triggered by a serine/ threonine protein kinase, sometimes called the M-phase promoting factor (MPF) kinase. This kinase consists of two subunits: a 34-kD catalytic subunit and a 45–60-kD regulatory subunit. The regulatory subunit is a member of the cyclin B family of proteins, which are produced during...
