Thioredoxin-interacting protein (TXNIP) mediates thioredoxin-dependent antioxidant mechanism in endometrial cancer cells treated with 1α, 25-dihydroxyvitamin D3

Y Kim, YS Kim, M Kim, JM Kim, HH Lee… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: To determine the mechanism of vitamin D3-induced modulation of
antioxidant-related factors in endometrial cancer, we investigated their role in apoptosis of …

Effect of Curcumin on Gene Expression of Trx/TxrR System and PI3K/Akt/mTOR Signaling Pathway in SKOV3 Cells Resistant to Cisplatin

EV Kalinina, A Hasan, AS Petrova… - Free Radical Biology & …, 2020 - elibrary.ru
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), plays the important roles in
controlling the cellular redox balance in cancer cells. Trx/TrxR-regulatory redox pathways …

[HTML][HTML] TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation

J Li, Z Yue, W Xiong, P Sun, K You… - Oncology …, 2017 - spandidos-publications.com
Thioredoxin binding protein (thioredoxin-interacting protein, TXNIP), known as vitamin D3
increase protein 1, has been identified as a tumor suppressor in various cancers such as …

[HTML][HTML] TXNIP: a double-edged sword in disease and therapeutic outlook

M Pan, F Zhang, K Qu, C Liu, J Zhang - Oxidative Medicine and …, 2022 - hindawi.com
Thioredoxin-interacting protein (TXNIP) was originally named vitamin D 3 upregulated
protein-1 (VDUP1) because of its ability to bind to thioredoxin (TRX) and inhibit TRX function …

[HTML][HTML] Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling

Y Qu, J Wang, PS Ray, H Guo, J Huang… - The Journal of …, 2011 - Am Soc Clin Investig
Cancer cells have an efficient antioxidant system to counteract their increased generation of
ROS. However, whether this ability to survive high levels of ROS has an important role in the …

Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells

X Chen, W Tang, S Liu, L Yu, Z Chen - Life sciences, 2010 - Elsevier
AIMS: Thioredoxin-1 (Trx) is an important protein involved in the regulation of apoptosis and
in enhancing drug resistance in cancer cells. Threonine100 (T100) of Trx was reported to be …

Thioredoxin Regulates Cell Cycle via the ERK1/2-Cyclin D1 Pathway

M Mochizuki, YW Kwon, J Yodoi… - Antioxidants & redox …, 2009 - liebertpub.com
Thioredoxin (TRX) is a key component of redox regulation and has been indicated to play an
essential role in cell survival and growth. Here, we investigated the molecular mechanism of …

Nuclear thioredoxin-1 is required to suppress cisplatin-mediated apoptosis of MCF-7 cells

XP Chen, S Liu, WX Tang, ZW Chen - Biochemical and biophysical …, 2007 - Elsevier
Different cell line with increased thioredoxin-1 (Trx-1) showed a decreased or increased
sensitivity to cell killing by cisplatin. Recently, several studies found that the subcellular …

Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-κB pathway

Y Lu, X Zhao, G Luo, G Shen, K Li, G Ren, Y Pan… - Cancer letters, 2015 - Elsevier
Our previous work identified thioredoxin-like protein 2 (Txl-2), a novel thioredoxin family
member, as the target of the monoclonal antibody MC3 which can detect colon cancer with …

TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion

J Zhang, X Tian, H Yin, S Xiao, S Yi… - The journal of …, 2020 - academic.oup.com
Evidence has indicated the associations between thioredoxin-interacting protein (TXNIP)
and cancers. However, the role of TXNIP in cervical cancer remains unclear. Hence, this …