The PPARγ antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARγ-dependent and-independent mechanisms

YY Zaytseva, NK Wallis, RC Southard… - Anticancer …, 2011 - ar.iiarjournals.org
Background: Peroxisome proliferator-activated receptor gamma (PPARγ) is overexpressed
in many types of cancer, including breast cancer, and it is regulated by ligand binding and …

[HTML][HTML] Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells

YY Zaytseva, X Wang, RC Southard, NK Wallis… - Molecular Cancer, 2008 - Springer
Background Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the
nuclear hormone receptor superfamily and is highly expressed in many human tumors …

The role of peroxisome proliferator-activated receptor-γ in breast cancer

I Kotta-Loizou, C Giaginis… - Anti-Cancer Agents in …, 2012 - ingentaconnect.com
Peroxisome Proliferator-Activated Receptor-γ (PPARγ) is an extensively studied ligand-
activated nuclear hormone receptor that functions as transcription factor and plays an …

[HTML][HTML] The role of PPARγ ligands in breast cancer: from basic research to clinical studies

G Augimeri, C Giordano, L Gelsomino, P Plastina… - Cancers, 2020 - mdpi.com
Simple Summary Breast cancer represents the most frequently diagnosed carcinoma and
the leading cause of cancer death in women. Despite advances achieved in systemic …

Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity

PL Yao, JL Morales, B Zhu, BH Kang… - Molecular cancer …, 2014 - AACR
The effect of activation and overexpression of the nuclear receptor PPAR-β/δ in human MDA-
MB-231 (estrogen receptor–negative; ER−) and MCF7 (estrogen-receptor-positive; ER+) …

Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells

CE Clay, AM Namen, G Atsumi… - Journal of …, 2001 - journals.sagepub.com
Background The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has
become a potential target for the prevention and treatment of breast cancer. However, recent …

GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently …

JM Seargent, EA Yates, JH Gill - British journal of …, 2004 - Wiley Online Library
Peroxisome proliferator‐activated receptor gamma (PPARγ), a member of the nuclear
receptor superfamily, is activated by several compounds, including the thiazolidinediones. In …

Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer

R Abduljabbar, MM Al-Kaabi, OH Negm… - Breast cancer research …, 2015 - Springer
Peroxisome proliferator-activated receptor-gamma (PPAR γ) is an adopted orphan receptor
that belongs to the nuclear receptor superfamily of transcription factors. PPAR γ is regarded …

The antiproliferative effects of PPARγ ligands in normal human mammary epithelial cells

LD Yee, Y Guo, J Bradbury, S Suster… - Breast cancer research …, 2003 - Springer
Peroxisome proliferator-activated receptor γ (PPARγ) is a transcription factor in the steroid
nuclear receptor superfamily. Ligand activation of PPARγ is associated with differentiation …

Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells

HN Yu, EM Noh, YR Lee, SG Roh, EK Song… - Biochemical and …, 2008 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been identified as a
potential source of therapy for human cancers. However, PPARγ ligands have a limitation for …