Demethoxycurcumin-induced DNA damage decreases DNA repair-associated protein expression levels in NCI-H460 human lung cancer cells

YC Ko, JC Lien, HC Liu, SC Hsu, HY Lin… - Anticancer …, 2015 - ar.iiarjournals.org
Demethoxycurcumin (DMC) is a key component of Chinese medicine (Turmeric) and has
been proven effective in killing various cancer cells. Its role in inducing cytotoxic effects in …

Bisdemethoxycurcumin induces DNA damage and inhibits DNA repair associated protein expressions in NCI‐H 460 human lung cancer cells

CC Yu, ST Yang, WW Huang, SF Peng… - Environmental …, 2016 - Wiley Online Library
Nonsmall cell lung carcinoma (NSCLC) is a devastating primary lung tumor resistant to
conventional therapies. Bisdemethoxycurcumin (BDMC) is one of curcumin derivate from …

Curcumin triggers DNA damage and inhibits expression of DNA repair proteins in human lung cancer cells

CY Ting, HE Wang, CC Yu, HC Liu, YC Liu… - Anticancer …, 2015 - ar.iiarjournals.org
The study goal was to evaluate the effects of curcumin on DNA damage and expression of
DNA-repair proteins in human lung cancer. Thus, NCI-H460 cells were used to study the …

Demethoxycurcumin alters gene expression associated with DNA damage, cell cycle and apoptosis in human lung cancer NCI-H460 cells in vitro

YC Ko, SC Hsu, HC Liu, YT Hsiao, TC Hsia, ST Yang… - in vivo, 2015 - iv.iiarjournals.org
Lung cancer is the leading cause of cancer-related deaths and new lung cancer cases are
continuously emerging around the globe; however, treatment of lung cancer remains …

[HTML][HTML] Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells

HS Shang, CH Chang, YR Chou… - Oncology …, 2016 - spandidos-publications.com
Cervical cancer is one of the most common cancers in women worldwide and it is a
prominent cause of cancer mortality. Curcumin is one of the major compounds from Turmeric …

[HTML][HTML] Demethoxycurcumin increases the sensitivity of cisplatin‑resistant non‑small lung cancer cells to cisplatin and induces apoptosis by activating the caspase …

Y Chen, C Hong, X Chen, Z Qin - Oncology Letters, 2020 - spandidos-publications.com
Patients with non‑small cell lung cancer (NSCLC) can develop strong drug resistance
following long‑term treatment with platinum‑based drugs. Increasing doses of …

[HTML][HTML] Curcumin-induced DNA demethylation in human gastric cancer cells is mediated by the DNA-damage response pathway

R Tong, X Wu, Y Liu, Y Liu, J Zhou, X Jiang… - … Medicine and Cellular …, 2020 - hindawi.com
Curcumin, a natural polyphenol antioxidant extracted from the root of turmeric (Curcuma
longa), can induce apoptosis and DNA demethylation in several types of cancer cells …

[HTML][HTML] Mitotic spindle defects and DNA damage induced by dimethoxycurcumin lead to an intrinsic apoptosis pathway in HepG2/C3A cells

TA Zanetti, BI Biazi, GC Coatti, A Baranoski… - Toxicology In Vitro, 2019 - Elsevier
Dimethoxycurcumin (DiMC), a synthetic analog of curcumin, was shown to have
antiproliferative activity in human tumor cell lines. Therefore, we investigated its cytotoxic …

[HTML][HTML] Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in …

I Chiang, WS Wang, HC Liu, ST Yang… - Oncology …, 2015 - spandidos-publications.com
Lung cancer is the most common cause of cancer mortality and new cases are on the
increase worldwide. However, the treatment of lung cancer remains unsatisfactory …

[HTML][HTML] Effects of demethoxycurcumin on the viability and apoptosis of skin cancer cells

Y Wu, P Zhang, H Yang, Y Ge… - Molecular Medicine …, 2017 - spandidos-publications.com
The present study investigated the effects and mechanisms of demethoxycurcumin (DMC)
on a human skin squamous cell carcinoma cell line, A431, and a human keratinocyte cell …