Phosphoinositide 3-kinase enhancer (PIKE) belongs to a family of GTP-binding proteins,
including three isoforms, PIKE-S, PIKE-L and PIKE-A. PIKE-S and PIKE-L interact with PI3K …

• Introduction• The structure, tissue distribution and cellular localization of PIKEs• Mitogenic
PIKE‐S signaling in the nucleus• Anti‐apoptotic function of PIKE‐L in neurons• Role of PIKE …

PIKE-A (PIKE-activating A kt), an isoform of PIKE GTPase that enhances
phosphatidylinositol 3-kinase (PI3-kinase) activity, specifically binds to active Akt but not PI3 …

Abstract PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously
expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a …

Akt/PKB is a crucial regulator of diverse cellular processes and contributes to cancer
progression. Activation of Akt is essentially dependent on phosphatidylinositol (PI) 3-kinase …

Isoform A of phosphatidylinositol 3-kinase enhancer (PIKE-A) is a newly identified
prooncogenic factor that has been implicated in cancer cell growth. How PIKE-A activity is …

Tumorigenesis is the process by which normal cells evolve the capacity to evade and
overcome the constraints usually placed upon their growth and survival. To ensure the …

Since its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been
recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3 …

GTP-binding proteins are the molecular switches of numerous cellular functions, including
migration, proliferation, and differentiation. In the past 10 years, we have characterized a …

Abstract PIKE (PI 3-K inase E nhancer) is a recently identified brain specific nuclear GTPase,
which binds PI 3-kinase and stimulates its lipid kinase activity. Nerve growth factor treatment …