Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice
Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory
epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to …
epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to …
[HTML][HTML] Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis
S Norwood, J Liao, BD Hammock… - American journal of …, 2010 - ncbi.nlm.nih.gov
Chronic inflammation is an important factor contributing to human carcinoma, and non-
steroidal anti-inflammatory drugs (NSAIDs) have been shown to have a preventive effect in …
steroidal anti-inflammatory drugs (NSAIDs) have been shown to have a preventive effect in …
Reduction of inflammatory bowel disease‐induced tumor development in IL‐10 knockout mice with soluble epoxide hydrolase gene deficiency
Soluble epoxide hydrolase (sEH) quickly inactivates anti‐inflammatory epoxyeicosatrienoic
acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs). Inhibition of sEH …
acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs). Inhibition of sEH …
Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10 (−/−) mice
Background Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory
epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives …
epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives …
[HTML][HTML] Epoxy-oxylipins and soluble epoxide hydrolase metabolic pathway as targets for NSAID-induced gastroenteropathy and inflammation-associated …
RD Jones, J Liao, X Tong, D Xu, L Sun, H Li… - Frontiers in …, 2019 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are
made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function …
made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function …
Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation
Obesity is associated with enhanced colonic inflammation, which is a major risk factor for
colorectal cancer. Considering the obesity epidemic in Western countries, it is important to …
colorectal cancer. Considering the obesity epidemic in Western countries, it is important to …
[HTML][HTML] Soluble epoxide hydrolase contributes to cell senescence and ER stress in aging mice Colon
Aging, which is characterized by enhanced cell senescence and functional decline of
tissues, is a major risk factor for many chronic diseases. Accumulating evidence shows that …
tissues, is a major risk factor for many chronic diseases. Accumulating evidence shows that …
Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide …
YE Qiu, J Qin, Y Luo, SL Qin, YF Mu, R Cun… - Prostaglandins & other …, 2018 - Elsevier
Background Previous preclinical evidence has suggested that the elevation of
epoxyeicosatrienoic acids (EETs) derived from the cytochrome P450 (CYP) epoxygenases …
epoxyeicosatrienoic acids (EETs) derived from the cytochrome P450 (CYP) epoxygenases …
Soluble epoxide hydrolase deficiency promotes liver regeneration and ameliorates liver injury in mice by regulating angiocrine factors and angiogenesis
W Deng, T Hu, W Xiong, X Jiang, Y Cao, Z Li… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background Soluble epoxide hydrolase (sEH) is a key enzyme for the hydrolysis of
epoxyeicosatrienoic acids (EETs) and has been implicated in the pathogenesis of hepatic …
epoxyeicosatrienoic acids (EETs) and has been implicated in the pathogenesis of hepatic …
[HTML][HTML] Inhibition of soluble epoxide hydrolase for renal health
JY Liu - Frontiers in Pharmacology, 2019 - frontiersin.org
A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the
corresponding vicinal diols, which are usually inactive or less active than the epoxide …
corresponding vicinal diols, which are usually inactive or less active than the epoxide …
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