Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice

W Zhang, H Li, HUA Dong, JIE Liao… - Anticancer …, 2013 - ar.iiarjournals.org
Soluble epoxide hydrolase (sEH) hydrolyses/inactivates anti-inflammatory
epoxyeicosatrienoic acids (EETs) to their corresponding diols, and targeting sEH leads to …

[HTML][HTML] Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis

S Norwood, J Liao, BD Hammock… - American journal of …, 2010 - ncbi.nlm.nih.gov
Chronic inflammation is an important factor contributing to human carcinoma, and non-
steroidal anti-inflammatory drugs (NSAIDs) have been shown to have a preventive effect in …

Reduction of inflammatory bowel disease‐induced tumor development in IL‐10 knockout mice with soluble epoxide hydrolase gene deficiency

W Zhang, J Liao, H Li, H Dong, H Bai… - Molecular …, 2013 - Wiley Online Library
Soluble epoxide hydrolase (sEH) quickly inactivates anti‐inflammatory epoxyeicosatrienoic
acids (EETs) by converting them to dihydroxyeicosatrienoic acids (DHETs). Inhibition of sEH …

Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10 (−/−) mice

W Zhang, AL Yang, J Liao, H Li, H Dong… - Digestive diseases and …, 2012 - Springer
Background Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory
epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives …

[HTML][HTML] Epoxy-oxylipins and soluble epoxide hydrolase metabolic pathway as targets for NSAID-induced gastroenteropathy and inflammation-associated …

RD Jones, J Liao, X Tong, D Xu, L Sun, H Li… - Frontiers in …, 2019 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are
made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function …

Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

W Wang, J Yang, J Zhang, Y Wang… - Proceedings of the …, 2018 - National Acad Sciences
Obesity is associated with enhanced colonic inflammation, which is a major risk factor for
colorectal cancer. Considering the obesity epidemic in Western countries, it is important to …

[HTML][HTML] Soluble epoxide hydrolase contributes to cell senescence and ER stress in aging mice Colon

W Wang, KM Wagner, Y Wang, N Singh… - International journal of …, 2023 - mdpi.com
Aging, which is characterized by enhanced cell senescence and functional decline of
tissues, is a major risk factor for many chronic diseases. Accumulating evidence shows that …

Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide …

YE Qiu, J Qin, Y Luo, SL Qin, YF Mu, R Cun… - Prostaglandins & other …, 2018 - Elsevier
Background Previous preclinical evidence has suggested that the elevation of
epoxyeicosatrienoic acids (EETs) derived from the cytochrome P450 (CYP) epoxygenases …

Soluble epoxide hydrolase deficiency promotes liver regeneration and ameliorates liver injury in mice by regulating angiocrine factors and angiogenesis

W Deng, T Hu, W Xiong, X Jiang, Y Cao, Z Li… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background Soluble epoxide hydrolase (sEH) is a key enzyme for the hydrolysis of
epoxyeicosatrienoic acids (EETs) and has been implicated in the pathogenesis of hepatic …

[HTML][HTML] Inhibition of soluble epoxide hydrolase for renal health

JY Liu - Frontiers in Pharmacology, 2019 - frontiersin.org
A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the
corresponding vicinal diols, which are usually inactive or less active than the epoxide …