Combination of biochanin A and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme
Background/Aim: Several epidemiological studies have reported the chemopreventive
potential of biochanin A, in cancer development and progression. We investigated the …
potential of biochanin A, in cancer development and progression. We investigated the …
[HTML][HTML] Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation
Q Dong, Q Li, L Duan, H Yin, X Wang, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a
flavonoid phenolic compound found in edible and herbal plants, has antioxidative and …
flavonoid phenolic compound found in edible and herbal plants, has antioxidative and …
The effect of biochanin A on cell growth, apoptosis, and migration in osteosarcoma cells
Y Zhao, L Wang, X Zhai, T Cui… - Die Pharmazie-An …, 2018 - ingentaconnect.com
Biochanin A has been reported to be associated to tumour cell proliferation, apoptosis and
drug resistance in hepatocellular carcinoma, prostate cancer, and colorectal cancer, etc …
drug resistance in hepatocellular carcinoma, prostate cancer, and colorectal cancer, etc …
Biochanin A sensitizes glioblastoma to temozolomide by inhibiting autophagy
Q Dong, D Wang, L Li, J Wang, Q Li, L Duan… - Molecular …, 2022 - Springer
Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in
patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a …
patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a …
Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.
X Lai, Y Li, M Gao - Oncology research, 2018 - europepmc.org
Non-small cell lung cancer (NSCLC) is the most common lung cancer with 15.9% of
predicted 5-year survival rate which represents extremely poor prognosis. In this study, we …
predicted 5-year survival rate which represents extremely poor prognosis. In this study, we …
[HTML][HTML] Biochanin A induces S phase arrest and apoptosis in lung cancer cells
Y Li, H Yu, F Han, M Wang, Y Luo, X Guo - BioMed research …, 2018 - hindawi.com
Lung cancer is among the most common malignancies with a poor 5-year survival rate
reaching only 16%. Thus, new effective treatment modalities and drugs are urgently needed …
reaching only 16%. Thus, new effective treatment modalities and drugs are urgently needed …
Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition
Abstract Purpose Glioblastomas (GBM) comprise 17% of all primary brain tumors. These
tumors are extremely aggressive due to their infiltrative capacity and chemoresistance, with …
tumors are extremely aggressive due to their infiltrative capacity and chemoresistance, with …
[HTML][HTML] The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma
Y Xiao, Q Gong, W Wang, F Liu, Q Kong, F Pan… - Cancer Cell …, 2020 - Springer
Background Hepatocellular carcinoma (HCC) is the most aggressive and frequently
diagnosed malignancy of the liver. Despite aggressive therapy, life expectancy of many …
diagnosed malignancy of the liver. Despite aggressive therapy, life expectancy of many …
[HTML][HTML] Biochanin A modulates cell viability, invasion, and growth promoting signaling pathways in HER-2-positive breast cancer cells
V Sehdev, JCK Lai, A Bhushan - Journal of oncology, 2009 - hindawi.com
Overexpression of HER-2 receptor is associated with poor prognosis and aggressive forms
of breast cancer. Scientific literature indicates a preventive role of isoflavones in cancer …
of breast cancer. Scientific literature indicates a preventive role of isoflavones in cancer …
[HTML][HTML] Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments
W Ge, G Yuan, D Wang, L Dong - Scientific Reports, 2024 - nature.com
Glioblastoma (GBM) is the most aggressive brain tumor and is characterized by a poor
prognosis and high recurrence and mortality rates. Biochanin A (BCA) exhibits promising …
prognosis and high recurrence and mortality rates. Biochanin A (BCA) exhibits promising …