Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells

VE Steele, JT Arnold, H Le, G Izmirlian… - Anticancer …, 2006 - ar.iiarjournals.org
Background: DHEA is widely used as a dietary supplement in older men. Because DHEA
can be converted to androgens or estrogens, such use may promote prostate cancer. In this …

Androgen receptor or estrogen receptor‐β blockade alters DHEA‐, DHT‐, and E2‐induced proliferation and PSA production in human prostate cancer cells

JT Arnold, X Liu, JD Allen, H Le, KK McFann… - The …, 2007 - Wiley Online Library
BACKGROUND Dehydroepiandrosterone (DHEA) is an endogenous steroid that is
metabolized to androgens and/or estrogens in the human prostate. DHEA levels decline …

Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells

JT Arnold, H Le, KK McFann… - American Journal of …, 2005 - journals.physiology.org
Serum levels of the adrenal androgen dehydroepiandrosterone (DHEA) peak in men and
women in the third decade of life and decrease progressively with age. Increasing numbers …

Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells

JT Arnold, NE Gray, K Jacobowitz… - The Journal of steroid …, 2008 - Elsevier
Dehydroepiandrosterone (DHEA) is commonly used as a dietary supplement and may affect
prostate pathophysiology when metabolized to androgens and/or estrogens. Human …

Does DHEA exert direct effects on androgen and estrogen receptors, and does it promote or prevent prostate cancer?

JT Arnold, MR Blackman - Endocrinology, 2005 - academic.oup.com
Dehydroepiandrosterone (DHEA) is produced by the adrenal cortex and is the most
abundant steroid in humans. Serum levels of DHEA and its sulfated conjugation product …

DHEA metabolism in prostate: For better or worse?

JT Arnold - Molecular and cellular endocrinology, 2009 - Elsevier
Dehydroepiandrosterone (DHEA) is commonly used in the USA as a nutritional supplement
for antiaging, metabolic support or other uses. Investigations into understanding the effects …

Dehydroepiandrosterone inhibits B16 mouse melanoma cell growth by induction of differentiation.

S Kawai, N Yahata, S Nishida, K Nagai… - Anticancer …, 1995 - europepmc.org
Background Low serum concentrations of dehydroepiandrosterone (DHEA) and its sulfate
are associated with an increased incidence of various human malignancies. DHEA has …

Differential biological effects of dehydroepiandrosterone (DHEA) between mouse (B16F10) and human melanoma (BLM) cell lines

K Joshi, SS Hassan, P Ramaraj - Dermato-endocrinology, 2017 - Taylor & Francis
Dehydroepiandrosterone (DHEA) is a weak androgen and had been shown to have anti-
cancer, anti-adipogenic and anti-inflammatory effects on mouse and other rodent models …

Endocrine-immune-paracrine interactions in prostate cells as targeted by phytomedicines

NE Gray, X Liu, R Choi, MR Blackman… - Cancer Prevention …, 2009 - AACR
Dehydroepiandrosterone (DHEA) is used as a dietary supplement and can be metabolized
to androgens and/or estrogens in the prostate. We investigated the hypothesis that DHEA …

Oral dehydroepiandrosterone inhibits the growth of human pancreatic cancer in nude mice

P Muscarella, LG Boros, WE Fisher, C Rink… - Journal of surgical …, 1998 - Elsevier
Background. Dehydroepiandrosterone (DHEA), an androgen precursor, inhibits the
induction of pancreatic cancer in some animal models. Our laboratory has previously …