Novel human NK cell line carrying CAR targeting EGFRvIII induces antitumor effects in glioblastoma cells
T Murakami, T Nakazawa, A Natsume… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Natural killer (NK) cells are considered potential antitumor effector cells.
The aim of this study was to establish a novel type of a chimeric antigen receptor (CAR) NK …
The aim of this study was to establish a novel type of a chimeric antigen receptor (CAR) NK …
Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances …
Epidermal growth factor receptor (EGFR) and its mutant form EGFRvIII are overexpressed in
a large proportion of glioblastomas (GBM). Immunotherapy with an EGFRvIII-specific …
a large proportion of glioblastomas (GBM). Immunotherapy with an EGFRvIII-specific …
[HTML][HTML] CAR-engineered NK cells targeting wild-type EGFR and EGFRvIII enhance killing of glioblastoma and patient-derived glioblastoma stem cells
J Han, J Chu, W Keung Chan, J Zhang, Y Wang… - Scientific reports, 2015 - nature.com
Glioblastoma (GB) remains the most aggressive primary brain malignancy. Adoptive transfer
of chimeric antigen receptor (CAR)-modified immune cells has emerged as a promising anti …
of chimeric antigen receptor (CAR)-modified immune cells has emerged as a promising anti …
EGFR and c-Met cross talk in glioblastoma and its regulation by human cord blood stem cells
KK Velpula, VR Dasari, S Asuthkar, B Gorantla… - Translational …, 2012 - Elsevier
Receptor tyrosine kinases (RTK) and their ligands control critical biologic processes, such
as cell proliferation, migration, and differentiation. Aberrant expression of these receptor …
as cell proliferation, migration, and differentiation. Aberrant expression of these receptor …
[HTML][HTML] Antitumor efficacy of chimeric antigen receptor T cells against EGFRvIII-expressing glioblastoma in C57BL/6 mice
M Chen, R Sun, B Shi, Y Wang, S Di, H Luo… - Biomedicine & …, 2019 - Elsevier
Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in
hematological tumors. However, many challenges remain in improving the efficacy of CAR T …
hematological tumors. However, many challenges remain in improving the efficacy of CAR T …
[HTML][HTML] Development of c‑MET‑specific chimeric antigen receptor‑engineered natural killer cells with cytotoxic effects on human liver cancer HepG2 cells
B Liu, ZZ Liu, ML Zhou, JW Lin… - Molecular …, 2019 - spandidos-publications.com
In recent years, cellular immunotherapy has served an important role in the combined
treatment of hepatocellular carcinoma. The possibility of specific cell therapies for the …
treatment of hepatocellular carcinoma. The possibility of specific cell therapies for the …
ErbB2/HER2-specific NK cells for targeted therapy of glioblastoma
Background: Glioblastoma (GBM) is the most common and malignant intracranial tumor in
adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM …
adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM …
Combined antitumor effects of anti-EGFR variant III CAR-T cell therapy and PD-1 checkpoint blockade on glioblastoma in mouse model
Y Song, Q Liu, T Zuo, G Wei, S Jiao - Cellular Immunology, 2020 - Elsevier
Glioblastoma is one of the deadliest cancers. Chimeric antigen receptor (CAR)-T cell
therapy against solid tumors has been far from satisfactory largely due to the …
therapy against solid tumors has been far from satisfactory largely due to the …
[PDF][PDF] Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors
AL Portillo, R Hogg, SM Poznanski, EA Rojas… - Iscience, 2021 - cell.com
Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against
hematologic malignancies, severe off-tumor effects have constrained their use against solid …
hematologic malignancies, severe off-tumor effects have constrained their use against solid …
The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor–positive tumor cells is enhanced by cytokines
JM Roda, T Joshi, JP Butchar, JW McAlees… - Clinical Cancer …, 2007 - AACR
Purpose: Natural killer (NK) cells express an activating Fc receptor (FcγRIIIa) that mediates
antibody-dependent cellular cytotoxicity (ADCC) and production of immune modulatory …
antibody-dependent cellular cytotoxicity (ADCC) and production of immune modulatory …