Background: Malignant tumors inhibit antitumor immune responses, which are driven by T-
regulatory cells or myeloid-derived suppressor cells (MDSCs). Since MDSCs are involved in …

Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells
accumulated in most cancer patients and mouse tumor models. MDSCs suppress host …

The tumor microenvironment is a complex and heterogeneous milieu in which multiple
interactions occur between tumor and host cells. Immunosuppressive cells which are …

Paradoxically, tumor development and progression can be inhibited and promoted by the
immune system. After three stages of immune editing, namely, elimination, homeostasis and …

Myeloid-derived suppressor cells (MDSC) are one of the major cell populations responsible
for regulating immune responses. These cells have been reported to accumulate in the …

As more groups investigate the role of myeloid-derived suppressor cells (MDSCs) in
promoting the growth of primary tumors and distant tumor metastases, it is imperative to …

Purpose: Myeloid-derived suppressor cells (MDSC) have emerged as an immune-regulatory
cell type that is expanded in tumor-bearing mice, but less is known about their immune …

3059 Background: A suppression of cell mediated immunity and malnutrition are commonly
seen in patients with advanced cancer and it has been reported that chronic inflammation …

Chronic inflammatory state can create a proper environment for neoplastic onset and sustain
cancer growth. The inflammatory state that arises at the tumor edge could contribute to …

The tumour microenvironment is a heterogeneous and complex environment, characterized
by the presence of malignant cells and non-neoplastic cellular elements, including immune …