Evaluation of 111In-labeled anginex as potential SPECT tracer for imaging of tumor angiogenesis

TR Van Mourik, T Läppchen, R Rossin… - Anticancer …, 2015 - ar.iiarjournals.org
Angiogenesis is a prerequisite for solid tumors to grow and metastasize, providing oxygen
and nutrients to the tumor site. The protein galectin-1 has been identified to be …

Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature

M Upreti, A Jamshidi-Parsian, S Apana… - Journal of molecular …, 2013 - Springer
The present study reports on a new strategy for selective, radiation therapy-amplified drug
delivery using an antiangiogenic 33-aa, tumor vasculature-targeting ligand, anginex, to …

Synthesis of [18F]anginex with high specific activity [18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors

SM Apana, RJ Griffin, NA Koonce… - Journal of Labelled …, 2011 - Wiley Online Library
Anginex is a 33‐residue peptide that has been previously demonstrated to possess
antiangiogenic properties. To provide a tool to evaluate the regional biodistribution and …

111In-labeled galectin-3–targeting peptide as a SPECT agent for imaging breast tumors

SR Kumar, SL Deutscher - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Galectin-3 is a member of the galectin family of β-galactoside–binding animal lectins.
Galectin-3 is overexpressed in a wide range of neoplasms and is associated with tumor …

[HTML][HTML] The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins

E Salomonsson, VL Thijssen, AW Griffioen… - Journal of Biological …, 2011 - ASBMB
Angiogenesis is a key event in cancer progression and therefore a promising target in
cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the …

Monitoring tumour response to anti-angiogenic therapy with an F18-labeled angiogenesis imaging agent

L Allen, M Battle, J Goggi, LC Brava, J Cooper, R Lear… - 2009 - Soc Nuclear Med
450 Objectives The RGD-binding integrins α v β 3 and α v β 5, play key roles in tumour
angiogenesis. We examined an [18 F] labeled small peptide (AH111585) containing an …

Galectin-1 as a prognostic marker and therapeutic target in head and neck malignancies

R Griffin, P Gaffney, K Mayo, E McNiel, F Ondrey… - Cancer Research, 2007 - AACR
Abstract 4098 No therapies for advanced and recurrent squamous cell carcinoma of the
head and neck have achieved increased survival for those afflicted for decades. Therefore, it …

[HTML][HTML] In vivo preclinical assessment of novel 68Ga-labelled peptides for imaging of tumor associated angiogenesis using positron emission tomography imaging

N Dénes, A Kis, JP Szabó, I Jószai, I Hajdu… - Applied Radiation and …, 2021 - Elsevier
Formation and growth of metastases require a new vascular network. Angiogenesis plays an
essential role in the expansion and progression of most malignancies. A high number of …

Uptake of the angiogenesis PET tracer 68Ga-NODAGA-E [c (RGDyK)] 2 correlates strongly with angiopoietin-1 and angiopoietin-2 expression in human …

J Oxboel, M Brandt-Larsen, J Madsen, A Kjaer - 2016 - Soc Nuclear Med
1367 Objectives Validation of the angiogenesis PET tracer 68 Ga-NODAGA-E [c (RGDyK)] 2
targeting integrin α V β 3: comparison of tracer uptake (% ID/g) with gene expression of …

[HTML][HTML] Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe 64Cu-cyclam-RAFT-c …

ZH Jin, T Furukawa, M Claron, D Boturyn, JL Coll… - Angiogenesis, 2012 - Springer
Abstract 64 Cu-cyclam-RAFT-c (-RGDfK-) 4 is a novel multimeric positron emission
tomography (PET) probe for α V β 3 integrin imaging. Its uptake and α V β 3 expression in …