Evaluation of 111In-labeled anginex as potential SPECT tracer for imaging of tumor angiogenesis
TR Van Mourik, T Läppchen, R Rossin… - Anticancer …, 2015 - ar.iiarjournals.org
Angiogenesis is a prerequisite for solid tumors to grow and metastasize, providing oxygen
and nutrients to the tumor site. The protein galectin-1 has been identified to be …
and nutrients to the tumor site. The protein galectin-1 has been identified to be …
Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature
M Upreti, A Jamshidi-Parsian, S Apana… - Journal of molecular …, 2013 - Springer
The present study reports on a new strategy for selective, radiation therapy-amplified drug
delivery using an antiangiogenic 33-aa, tumor vasculature-targeting ligand, anginex, to …
delivery using an antiangiogenic 33-aa, tumor vasculature-targeting ligand, anginex, to …
Synthesis of [18F]anginex with high specific activity [18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors
SM Apana, RJ Griffin, NA Koonce… - Journal of Labelled …, 2011 - Wiley Online Library
Anginex is a 33‐residue peptide that has been previously demonstrated to possess
antiangiogenic properties. To provide a tool to evaluate the regional biodistribution and …
antiangiogenic properties. To provide a tool to evaluate the regional biodistribution and …
111In-labeled galectin-3–targeting peptide as a SPECT agent for imaging breast tumors
SR Kumar, SL Deutscher - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Galectin-3 is a member of the galectin family of β-galactoside–binding animal lectins.
Galectin-3 is overexpressed in a wide range of neoplasms and is associated with tumor …
Galectin-3 is overexpressed in a wide range of neoplasms and is associated with tumor …
[HTML][HTML] The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins
E Salomonsson, VL Thijssen, AW Griffioen… - Journal of Biological …, 2011 - ASBMB
Angiogenesis is a key event in cancer progression and therefore a promising target in
cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the …
cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the …
Monitoring tumour response to anti-angiogenic therapy with an F18-labeled angiogenesis imaging agent
L Allen, M Battle, J Goggi, LC Brava, J Cooper, R Lear… - 2009 - Soc Nuclear Med
450 Objectives The RGD-binding integrins α v β 3 and α v β 5, play key roles in tumour
angiogenesis. We examined an [18 F] labeled small peptide (AH111585) containing an …
angiogenesis. We examined an [18 F] labeled small peptide (AH111585) containing an …
Galectin-1 as a prognostic marker and therapeutic target in head and neck malignancies
Abstract 4098 No therapies for advanced and recurrent squamous cell carcinoma of the
head and neck have achieved increased survival for those afflicted for decades. Therefore, it …
head and neck have achieved increased survival for those afflicted for decades. Therefore, it …
[HTML][HTML] In vivo preclinical assessment of novel 68Ga-labelled peptides for imaging of tumor associated angiogenesis using positron emission tomography imaging
Formation and growth of metastases require a new vascular network. Angiogenesis plays an
essential role in the expansion and progression of most malignancies. A high number of …
essential role in the expansion and progression of most malignancies. A high number of …
Uptake of the angiogenesis PET tracer 68Ga-NODAGA-E [c (RGDyK)] 2 correlates strongly with angiopoietin-1 and angiopoietin-2 expression in human …
J Oxboel, M Brandt-Larsen, J Madsen, A Kjaer - 2016 - Soc Nuclear Med
1367 Objectives Validation of the angiogenesis PET tracer 68 Ga-NODAGA-E [c (RGDyK)] 2
targeting integrin α V β 3: comparison of tracer uptake (% ID/g) with gene expression of …
targeting integrin α V β 3: comparison of tracer uptake (% ID/g) with gene expression of …
[HTML][HTML] Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe 64Cu-cyclam-RAFT-c …
ZH Jin, T Furukawa, M Claron, D Boturyn, JL Coll… - Angiogenesis, 2012 - Springer
Abstract 64 Cu-cyclam-RAFT-c (-RGDfK-) 4 is a novel multimeric positron emission
tomography (PET) probe for α V β 3 integrin imaging. Its uptake and α V β 3 expression in …
tomography (PET) probe for α V β 3 integrin imaging. Its uptake and α V β 3 expression in …
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