Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo
T Nii, K Yoshikawa, I Takeuchi, K Makino - Anticancer research, 2022 - ar.iiarjournals.org
Background/Aim: The objective of this study was to prepare doxorubicin encapsulated in
micelles (DOX-micelles) using poly (hexadecanyloxyethylene glycol-lactate phosphate) …
micelles (DOX-micelles) using poly (hexadecanyloxyethylene glycol-lactate phosphate) …
Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems
The fate of polymeric micelles (PMs) is mainly determined by their physicochemical
properties, such as particle size, shape, and surface potential. Of these factors, the size …
properties, such as particle size, shape, and surface potential. Of these factors, the size …
Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system
S Jafarzadeh-Holagh, S Hashemi-Najafabadi… - Journal of colloid and …, 2018 - Elsevier
Nanocarrier-based drug delivery systems have been explored extensively in cancer therapy.
Among the vast number of different nanocarrier systems applied to deliver …
Among the vast number of different nanocarrier systems applied to deliver …
Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles
ML Gou, HS Shi, G Guo, K Men, J Zhang… - …, 2011 - iopscience.iop.org
In an attempt to improve anticancer activity and reduce systemic toxicity of doxorubicin
(Dox), we encapsulated Dox in monomethoxy poly (ethylene glycol)-poly (ε …
(Dox), we encapsulated Dox in monomethoxy poly (ethylene glycol)-poly (ε …
Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers
Designing stable drug nanocarriers, 10–30 nm in size, would have significant impact on
their transport in circulation, tumor penetration, and therapeutic efficacy. In the present study …
their transport in circulation, tumor penetration, and therapeutic efficacy. In the present study …
Biodegradable polymeric micelle-encapsulated doxorubicin suppresses tumor metastasis by killing circulating tumor cells
S Deng, Q Wu, Y Zhao, X Zheng, N Wu, J Pang, X Li… - Nanoscale, 2015 - pubs.rsc.org
Circulating tumor cells (CTCs) play a crucial role in tumor metastasis, but it is rare for any
chemotherapy regimen to focus on killing CTCs. Herein, we describe doxorubicin (Dox) …
chemotherapy regimen to focus on killing CTCs. Herein, we describe doxorubicin (Dox) …
The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles
Doxorubicin (DOX) is an effective chemotherapeutic against a wide range of solid tumors.
However, its clinical use is limited by severe side effects such as cardiotoxicity as well as …
However, its clinical use is limited by severe side effects such as cardiotoxicity as well as …
Antitumor activity of monomethoxy poly (ethylene glycol)-poly (ε-caprolactone) micelle-encapsulated doxorubicin against mouse melanoma
L Zheng, M Gou, S Zhou, T Yi, Q Zhong… - Oncology …, 2011 - spandidos-publications.com
Doxorubicin (Dox) is one of the most commonly used and highly effective antineoplastic
agents, but the clinical application of this broad spectrum drug is largely hampered by its …
agents, but the clinical application of this broad spectrum drug is largely hampered by its …
Cellular internalization of doxorubicin loaded star-shaped micelles with hydrophilic zwitterionic sulfobetaine segments
J Cao, X Xie, A Lu, B He, Y Chen, Z Gu, X Luo - Biomaterials, 2014 - Elsevier
Four arm star-shaped poly (ε-caprolactone)-b-poly ((N, N-diethylaminoethyl methacrylate)-r-
(N-(3-sulfopropyl)-N-methacryloxyethy-N, N-diethylammoniumbetaine))(4sPCLDEAS) …
(N-(3-sulfopropyl)-N-methacryloxyethy-N, N-diethylammoniumbetaine))(4sPCLDEAS) …
Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free …
M Cagel, MA Moretton, E Bernabeu, M Zubillaga… - Journal of Drug Delivery …, 2020 - Elsevier
Doxorubicin-loaded mixed micelles (DOX-micelles) were formulated employing TPGS and a
poloxamine (Tetronic® T1107) in order to investigate their pharmaceutical application as an …
poloxamine (Tetronic® T1107) in order to investigate their pharmaceutical application as an …
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