Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo

T Nii, K Yoshikawa, I Takeuchi, K Makino - Anticancer research, 2022 - ar.iiarjournals.org
Background/Aim: The objective of this study was to prepare doxorubicin encapsulated in
micelles (DOX-micelles) using poly (hexadecanyloxyethylene glycol-lactate phosphate) …

Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems

J Yue, S Liu, Z Xie, Y Xing, X Jing - Journal of Materials Chemistry B, 2013 - pubs.rsc.org
The fate of polymeric micelles (PMs) is mainly determined by their physicochemical
properties, such as particle size, shape, and surface potential. Of these factors, the size …

Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system

S Jafarzadeh-Holagh, S Hashemi-Najafabadi… - Journal of colloid and …, 2018 - Elsevier
Nanocarrier-based drug delivery systems have been explored extensively in cancer therapy.
Among the vast number of different nanocarrier systems applied to deliver …

Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles

ML Gou, HS Shi, G Guo, K Men, J Zhang… - …, 2011 - iopscience.iop.org
In an attempt to improve anticancer activity and reduce systemic toxicity of doxorubicin
(Dox), we encapsulated Dox in monomethoxy poly (ethylene glycol)-poly (ε …

Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers

N Dube, JY Shu, H Dong, JW Seo, E Ingham… - …, 2013 - ACS Publications
Designing stable drug nanocarriers, 10–30 nm in size, would have significant impact on
their transport in circulation, tumor penetration, and therapeutic efficacy. In the present study …

Biodegradable polymeric micelle-encapsulated doxorubicin suppresses tumor metastasis by killing circulating tumor cells

S Deng, Q Wu, Y Zhao, X Zheng, N Wu, J Pang, X Li… - Nanoscale, 2015 - pubs.rsc.org
Circulating tumor cells (CTCs) play a crucial role in tumor metastasis, but it is rare for any
chemotherapy regimen to focus on killing CTCs. Herein, we describe doxorubicin (Dox) …

The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles

TH Kim, CW Mount, WR Gombotz, SH Pun - Biomaterials, 2010 - Elsevier
Doxorubicin (DOX) is an effective chemotherapeutic against a wide range of solid tumors.
However, its clinical use is limited by severe side effects such as cardiotoxicity as well as …

Antitumor activity of monomethoxy poly (ethylene glycol)-poly (ε-caprolactone) micelle-encapsulated doxorubicin against mouse melanoma

L Zheng, M Gou, S Zhou, T Yi, Q Zhong… - Oncology …, 2011 - spandidos-publications.com
Doxorubicin (Dox) is one of the most commonly used and highly effective antineoplastic
agents, but the clinical application of this broad spectrum drug is largely hampered by its …

Cellular internalization of doxorubicin loaded star-shaped micelles with hydrophilic zwitterionic sulfobetaine segments

J Cao, X Xie, A Lu, B He, Y Chen, Z Gu, X Luo - Biomaterials, 2014 - Elsevier
Four arm star-shaped poly (ε-caprolactone)-b-poly ((N, N-diethylaminoethyl methacrylate)-r-
(N-(3-sulfopropyl)-N-methacryloxyethy-N, N-diethylammoniumbetaine))(4sPCLDEAS) …

Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free …

M Cagel, MA Moretton, E Bernabeu, M Zubillaga… - Journal of Drug Delivery …, 2020 - Elsevier
Doxorubicin-loaded mixed micelles (DOX-micelles) were formulated employing TPGS and a
poloxamine (Tetronic® T1107) in order to investigate their pharmaceutical application as an …