The synergistic effect of rapamycin combined with 5-fluorouracil in BALB/cByJNarl mice bearing CT-26 tumor cells
TH Chao, GR Chang, WY Chen, PL Chen… - Anticancer …, 2014 - ar.iiarjournals.org
Background: The aim of this study was to investigate the antitumor effect of rapamycin, an
inhibitor of mammalian target of rapamycin (mTOR) signaling, combined with 5-fluorouracil …
inhibitor of mammalian target of rapamycin (mTOR) signaling, combined with 5-fluorouracil …
Effective Targeting of Colorectal Cancer Cells using TORC1/2 Kinase Inhibitors In Vitro and In Vivo
J Zhang, W Jiang, W Liu, JJ Wu, L Song… - Future …, 2016 - Taylor & Francis
Aim: We investigated the effects of TORC1/2 kinase inhibitors on colorectal cancer (CRC)
cell lines. Materials & methods: Using selective TORC1/2 inhibitors, rapamycin and PP242 …
cell lines. Materials & methods: Using selective TORC1/2 inhibitors, rapamycin and PP242 …
Mammalian target of rapamycin is a promising target for novel therapeutic strategy against cancer.
SK Bjelogrlić, T Srdić, S Radulović - … of BU ON.: Official Journal of …, 2006 - europepmc.org
Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular
phosphatidylinositol 3-kinase (P13K) pathway. The P13K/Akt signaling pathway plays a …
phosphatidylinositol 3-kinase (P13K) pathway. The P13K/Akt signaling pathway plays a …
Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells
YJ Zhang, JY Fang, DF Sun, SL Zhao… - Zhonghua Zhong liu …, 2007 - europepmc.org
Objective To investigate the synergistic effect of rapamycin (RPM) and PD98059 on human
colorectal cancer cells and its potential mechanisms. Methods Three human colorectal …
colorectal cancer cells and its potential mechanisms. Methods Three human colorectal …
[PDF][PDF] Rapamycin inhibits the proliferation of SW1990 pancreatic cancer cell
M Xu, LM Bu, K Wu, LG Lu… - Eur Rev Med Pharmacol …, 2015 - europeanreview.org
OBJECTIVE: To study the effect of rapamycin on pancreatic cancer cell proliferation, we
designed a serial of experiments in human pancreatic cancer cell line SW1990. MATERIALS …
designed a serial of experiments in human pancreatic cancer cell line SW1990. MATERIALS …
Rapamycin enhances chemotherapy‐induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells
H Shigematsu, K Yoshida, Y Sanada… - … journal of cancer, 2010 - Wiley Online Library
We have previously reported the synergistic cytotoxic effects of Docetaxel (TXT) and S‐1 in
gastric cancer in vitro and in vivo, and the combination regimen is now under phase III …
gastric cancer in vitro and in vivo, and the combination regimen is now under phase III …
Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1
M Wagner, V Roh, M Strehlen, A Laemmle… - Journal of …, 2009 - Springer
Aim The mTOR-inhibitor rapamycin has shown antitumor activity in various tumors. Bedside
observations have suggested that rapamycin may be effective as a treatment for colorectal …
observations have suggested that rapamycin may be effective as a treatment for colorectal …
Rapamycin and CCI‐779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma
ICF Hui, EKK Tung, KMF Sze, YP Ching… - Liver …, 2010 - Wiley Online Library
Background: The mammalian target of rapamycin (mTOR), which phosphorylates p70S6K
and 4EBP1 and activates the protein translation process, is upregulated in cancers and its …
and 4EBP1 and activates the protein translation process, is upregulated in cancers and its …
Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells
D Ardjmand, Y Kubota, M Sato, Q Han… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Rapamycin and recombinant methioninase (rMETase) have both shown
efficacy to target cancer cells. Rapamycin prevents cancer-cell growth by inhibition of the …
efficacy to target cancer cells. Rapamycin prevents cancer-cell growth by inhibition of the …
[HTML][HTML] Antitumor effect of low-dose of rapamycin in a transgenic mouse model of liver cancer
HS Lee, JY Kim, SW Ro, MS Kim, H Kim… - Yonsei Medical …, 2022 - ncbi.nlm.nih.gov
Purpose We investigate whether low-dose rapamycin is effective in preventing
hepatocellular carcinoma (HCC) growth and treating HCC after tumor development in …
hepatocellular carcinoma (HCC) growth and treating HCC after tumor development in …