Expression of the serine protease hepsin and clinical outcome of human endometrial cancer

T Matsuo, K Nakamura, N Takamoto… - Anticancer …, 2008 - ar.iiarjournals.org
Background: Hepsin is a type II transmembrane serine protease originally identified in the
human liver as a cDNA clone. Hepsin was found to be significantly overexpressed in cancer …

The role of hepsin in endometrial carcinoma

HS El-Rebey, MAH Kandil, RM Samaka… - Applied …, 2017 - journals.lww.com
Purpose: Endometrial carcinoma is the sixth most common cancer in women worldwide and
the most common invasive cancer of the female genital tract in developed countries. It is …

Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer

H Tanimoto, Y Yan, J Clarke, S Korourian… - Cancer research, 1997 - AACR
Extracellular proteases mediate the digestion of neighboring extracellular matrix
components in initial tumor growth, allow shedding or desquamation of tumor cells into the …

Hepsin inhibits the cell growth of endometrial cancer

K Nakamura, N Takamoto… - International …, 2008 - spandidos-publications.com
Currently, several therapeutic approaches including surgery, chemotherapy, and radiation
therapy are available for the treatment of endometrial cancer. However, endometrial cancer …

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

JA Xuan, D Schneider, P Toy, R Lin, A Newton, Y Zhu… - Cancer research, 2006 - AACR
Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at
lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA …

Clinical and biological significance of hepsin overexpression in breast cancer

P Xing, J Li, F Jin, T Zhao, Q Liu… - Journal of …, 2011 - journals.sagepub.com
Objective Although many studies have documented the tumor-promoting role of hepsin in
several types of malignancies, little is known about its clinical and biological significance in …

Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines

K Nakamura, Y Nasu, A Hongo… - International …, 2006 - spandidos-publications.com
In light of the poor prognosis for ovarian cancer patients, the research continues for
innovative and efficacious treatment modalities. Along with surgical and chemotherapeutic …

Decreased expressions of hepsin in human hepatocellular carcinomas

CH Chen, KY Su, MH Tao, SW Lin, YH Su… - Liver …, 2006 - Wiley Online Library
Background/Aims: Hepsin is a type II transmembrane protein predominantly expressed in
the liver and has been implicated in participation in blood coagulation pathway and …

[HTML][HTML] Implication of hepsin from primary tumor in the prognosis of colorectal cancer patients

D Zaragoza-Huesca, A Nieto-Olivares, F García-Molina… - Cancers, 2022 - mdpi.com
Simple Summary Hepsin is a serine protease whose deregulation leads to tumor invasion
and metastasis in many tumor types. In colorectal cancer, the role of hepsin is unknown, so …

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model

J Miao, D Mu, B Ergel, R Singavarapu… - … journal of cancer, 2008 - Wiley Online Library
Hepsin is a serine protease that is widely expressed in different tissues and cell types, most
prominently in the normal liver and kidney. Overexpression of hepsin has been associated …