Background: Resistance to paclitaxel (PTX) is a major concern in treating ovarian cancer.
Thus, agents effective in taxane-resistant tumours are highly sought. It has recently been …

Tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors
have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. It …

This study aimed to test the antiproliferative effect of three benzimidazole anthelmintics in
intestinal cancer cells and to investigate whether these drugs, which inhibit tubulin …

Background: ABCB1 expression is uncommon in ovarian cancers in the clinical setting so
we investigated non-MDR mechanisms of resistance to taxanes. Methods: We established …

Background Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable
activity against a variety of human cancer cells. In this study, we examined if the antitumor …

Background The interaction between paclitaxel and its target, beta tubulin, is essential for
effective cytotoxicity. Alterations or mutation of beta tubulin have the potential to alter …

Background: Clinical response to chemotherapy for ovarian cancer is frequently
compromised by the development of drug-resistant disease. The underlying molecular …

OBJECTIVE: The objective of the study was to investigate whether azacitidine sensitizes
platinum-resistant ovarian cancer cells to carboplatin and the possible mechanisms …

BAL27862 is a synthetic small molecule that induces apoptosis due to the inhibition of
tubulin polymerization via a potentially new mechanism of action. The activity of this novel …

The aim of this study was to assess paclitaxel resistant-epithelial ovarian carcinoma (EOC)
cells for cellular morphology, motility, and molecular changes consistent with epithelial …