Recombinant interleukin-2 enhanced the antitumor effect of ADV/RSV-HSV-tk/ACV therapy in a murine bladder cancer model

S Terao, T Shirakawa, K Goda, S Kamidono… - Anticancer …, 2005 - ar.iiarjournals.org
Background: Previous studies demonstrated the antitumor effects of IL-2 and ADV/RSV-HSV-
tk in bladder tumor models. In our study, we employed the intramuscular injection of …

Adenovirus-mediated combination suicide and cytokine gene therapy for bladder cancer.

CT Freund, MA Sutton, T Dang, CF Contant… - Anticancer …, 2000 - europepmc.org
Background The present study tests the hypothesis that adenovirus-mediated transfer of
murine IL-2 (ADV/RSV-mIL-2) alone or in combination with HSV-tk+ GCV will improve …

Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8

K Inoue, CG Wood, JW Slaton… - Oncology …, 2001 - spandidos-publications.com
We previously demonstrated the importance of interleukin-8 (IL-8) as a mediator of
angiogenesis, tumorigenicity, and metastasis of transitional cell carcinoma (TCC) of the …

Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1

T Felzmann, WJ Ramsey, RM Blaese - Gene therapy, 1997 - nature.com
In a cancer gene therapy model recombinant adenoviruses expressing the herpes simplex
virus thymidine kinase (HSVtk) gene were injected into tumors in situ, either alone or in …

Potent antitumour activity of the combination of HSV‐TK and endostatin armed oncolytic adeno‐associated virus for bladder cancer in vitro and in vivo

JG Pan, X Zhou, GW Zeng… - Journal of surgical …, 2012 - Wiley Online Library
Background Gene therapy may offer a new tool for the treatment of bladder cancer.
Previously, we have shown a significant antitumour effect in bladder cancer xenografts in a …

Combination gene therapy with adenoviral vector-mediated HSV-tk+ GCV and IL-12 in an orthotopic mouse model for prostate cancer

Y Nasu, CH Bangma, GW Hull, G Yang… - Prostate Cancer and …, 2001 - nature.com
We previously demonstrated significant therapeutic activities associated with adenoviral
vector-mediated Herpes Simplex Virus/thymidine kinase (AdHSV-tk) with ganciclovir (GCV) …

The adeno-associated virus-mediated HSV-TK/GCV suicide system: a potential strategy for the treatment of bladder carcinoma

JG Pan, X Zhou, R Luo, RF Han - Medical oncology, 2012 - Springer
Novel treatment strategies such as gene therapy are warranted in view of the failure of
current treatment approaches to cure a high percentage of patients with advanced bladder …

Adenovirus-mediated interleukin-2 production by tumors induces growth of cytotoxic tumor-infiltrating lymphocytes against human renal cell carcinoma

P Mulders, CL Tso, S Pang, R Kaboo… - Journal of …, 1998 - journals.lww.com
Combination therapy with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes (TILs)
demonstrates significant clinical activity in patients with metastatic renal cell carcinoma …

Adenovirus‐mediated suicide‐gene therapy in an orthotopic murine bladder tumor model

J Cheon, DG Moon, HY Cho, HS Park… - … journal of urology, 2002 - Wiley Online Library
Background: Patients with high‐grade transitional‐cell carcinoma (TCC) of the bladder
frequently experience recurrence and progress and have a low response rate to …

Combination with CD/5‐FC gene therapy enhances killing of human bladder‐cancer cells by radiation

Z Zhang, T Shirakawa, N Hinata… - The Journal of Gene …, 2003 - Wiley Online Library
Background Resistance to radiation and chemotherapy is a significant obstacle to the
treatment of advanced bladder cancer. Gene therapy combined with radiation represents a …