Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells
SV Shrikhande, J Kleeff, H Kayed, S Keleg… - Anticancer …, 2006 - ar.iiarjournals.org
Background: The X-linked inhibitor of apoptosis (XIAP) belongs to a family of proteins that
suppresses apoptosis by inhibition of caspases in some cancers. It confers resistance to …
suppresses apoptosis by inhibition of caspases in some cancers. It confers resistance to …
XIAP is related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics
Y Li, Z Jian, K Xia, X Li, X Lv, H Pei, Z Chen, J Li - Pancreas, 2006 - journals.lww.com
Objectives: To explore the exact role does the x-linked inhibitor of apoptosis (XIAP) play in
chemoresistance of pancreatic carcinoma cell and the cell sensitivity to chemotherapeutic …
chemoresistance of pancreatic carcinoma cell and the cell sensitivity to chemotherapeutic …
[HTML][HTML] Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion
C Jiang, XP Yi, H Shen, YX Li - World Journal of Gastroenterology …, 2012 - ncbi.nlm.nih.gov
AIM: To determine whether lentivirus-mediated shRNA targeting the X-linked inhibitor of
apoptosis protein (XIAP) gene could be exploited in the treatment of pancreatic cancer …
apoptosis protein (XIAP) gene could be exploited in the treatment of pancreatic cancer …
[HTML][HTML] XIAP expression is associated with pancreatic carcinoma outcome
S Li, J Sun, J Yang, L Zhang… - Molecular and …, 2013 - spandidos-publications.com
Pancreatic carcinoma is an aggressive tumor that is resistant to treatment regimens.
Although the X-linked inhibitor of apoptosis protein (XIAP) overexpression in pancreatic …
Although the X-linked inhibitor of apoptosis protein (XIAP) overexpression in pancreatic …
X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells
A Amantana, CA London, PL Iversen, GR Devi - Molecular cancer …, 2004 - AACR
Androgen-insensitive prostate cancer cells are highly resistant to several chemotherapeutic
drugs and are characterized by the appearance of apoptosis-resistant cells. In this study, we …
drugs and are characterized by the appearance of apoptosis-resistant cells. In this study, we …
[HTML][HTML] XIAP underlies apoptosis resistance of renal cell carcinoma cells
WZ Yang, H Zhou, Y Yan - Molecular medicine reports, 2018 - spandidos-publications.com
X‑linked inhibitor of apoptosis (XIAP), a key member of the inhibitors of apoptosis protein
family, can inhibit apoptosis by directly binding to the initiator caspase‑9,‑3 and‑7, thereby …
family, can inhibit apoptosis by directly binding to the initiator caspase‑9,‑3 and‑7, thereby …
[HTML][HTML] Double inhibition of NF-κB and XIAP via RNAi enhances the sensitivity of pancreatic cancer cells to gemcitabine
LP Cao, JL Song, XP Yi, YX Li - Oncology reports, 2013 - spandidos-publications.com
The majority of patients with pancreatic cancer are resistant to gemcitabine. One of the
mechanisms involved is the anti-apoptotic ability of these cells. The median lethal dose …
mechanisms involved is the anti-apoptotic ability of these cells. The median lethal dose …
Downregulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells
X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis
protein (IAP) gene family in terms of its ability to inhibit caspases and suppress apoptosis …
protein (IAP) gene family in terms of its ability to inhibit caspases and suppress apoptosis …
X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise
H Kashkar - Clinical Cancer Research, 2010 - AACR
The X-linked inhibitor of apoptosis (XIAP) is the only cellular protein that has evolved to
potently inhibit the enzymatic activity of mammalian caspases and promotes resistance to …
potently inhibit the enzymatic activity of mammalian caspases and promotes resistance to …
Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma
K Shiraki, K Sugimoto… - International …, 2003 - spandidos-publications.com
The X-linked inhibitor of apoptosis (XIAP) is a member of a novel family of inhibitors of
apoptosis. Since suppression of apoptosis is fundamentally important for carcinogenesis …
apoptosis. Since suppression of apoptosis is fundamentally important for carcinogenesis …