Ephrin receptor A4 expression enhances migration, invasion and neurotropism in pancreatic ductal adenocarcinoma cells

S Furuhashi, Y Morita, S Ida, R Muraki… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: We sought to identify the mechanisms of perineural invasion in pancreatic
ductal adenocarcinoma (PDAC). Materials and Methods: We utilized in vitro cancer cell …

[HTML][HTML] Involvement of ephrin receptor A4 in pancreatic cancer cell motility and invasion

C Liu, H Huang, C Wang, Y Kong… - Oncology …, 2014 - spandidos-publications.com
Ephrin (EPH) receptors can be classified into EPHA and EPHB receptors and are important
in diverse cellular processes. EPHA4, a member of the EPHA receptors, has been …

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth

M Iiizumi, M Hosokawa, A Takehara, S Chung… - Cancer …, 2006 - Wiley Online Library
To isolate novel diagnostic markers and drug targets for pancreatic ductal adenocarcinoma
(PDAC), we previously performed expression profile analysis of PDAC cells using a genome …

RETRACTED ARTICLE: EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma

MS Duxbury, H Ito, MJ Zinner, SW Ashley, EE Whang - Oncogene, 2004 - nature.com
The EphA2 receptor tyrosine kinase is overexpressed in a variety of human cancers. We
sought to characterize the role of EphA2 in pancreatic adenocarcinoma and, using RNA …

EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic pathways

M Li, C Yang, X Liu, L Yuan, F Zhang, M Wang, D Miao… - Cancer Letters, 2016 - Elsevier
Abstract Ephrin Type-A Receptor 3 (EphA3) belongs to the ephrin receptor subfamily of the
protein tyrosine kinase family, and plays an important role in embryogenesis and …

[HTML][HTML] Inhibition of Eph receptor A4 by 2, 5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

H Takano, T Nakamura, T Tsuchikawa, T Kushibiki… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Ephrin receptor A4 (EphA4) is overexpressed in human pancreatic
adenocarcinoma (PDAC) and activate cell growth. Recent studies have identified small …

[HTML][HTML] EphA3 inhibits migration and invasion of esophageal cancer cells by activating the mesenchymal‑epithelial transition process

X Chen, B Lu, Q Ma, CD Ji, JZ Li - … journal of oncology, 2019 - spandidos-publications.com
Eph receptor tyrosine kinases are critical for cell‑cell communication during normal and
oncogenic development. Eph receptor A3 (EphA3) expression is associated with tumor …

Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status

SV Mudali, B Fu, SS Lakkur, M Luo… - Clinical & experimental …, 2006 - Springer
EphA2 is a transmembrane receptor tyrosine kinase that functions in the regulation of cell
growth, survival, angiogenesis, and migration and EphA2 targeting has been proposed as a …

Identification of therapeutic targets and prognostic biomarkers of the ephrin receptor subfamily in pancreatic adenocarcinoma

J Zou, K Zhang, J Zhu, C Tu… - Journal of International …, 2024 - journals.sagepub.com
Objectives We aimed to examine the significance of ephrin receptor A2 (EphA2) expression
in pancreatic adenocarcinoma (PAAD) and its associated mechanism. Methods EphA2 …

EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line

J Fukai, H Yokote, R Yamanaka, T Arao, K Nishio… - Molecular cancer …, 2008 - AACR
The Eph receptor tyrosine kinases and their ephrin ligands form a unique cell-cell contact-
mediated bidirectional signaling mechanism for regulating cell localization and organization …