Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (−)-gossypol

S Zhong, WP Ye, PP Xu, E Feng, H Li, SH Lin… - Anticancer …, 2010 - ar.iiarjournals.org
Background: Obesity is associated with an increased risk of estrogen-dependent breast
cancer. Recently, concerns have been raised regarding the role of zeranol (Z), a non …

Zeranol enhances leptin-induced proliferation in primary cultured human breast cancer epithelial cells

P Xu, W Ye, H Li, SH Lin, CT Kuo… - Molecular …, 2010 - spandidos-publications.com
Breast cancer is the leading type of cancer in women in the United States. One of the known
risk factors of breast cancer is obesity. Leptin is a product of the obese (ob) gene and plays …

Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol

P Xu, W Ye, R Jen, SH Lin, CT Kuo, YC Lin - Anticancer research, 2009 - ar.iiarjournals.org
Background: The molecular links between breast cancer and obesity have been studied for
many years. Obesity significantly increases the incidence rate and chance of morbidity of …

[HTML][HTML] Zeranol may increase the risk of leptin-induced neoplasia in human breast

P Xu, W Ye, S Zhong, R Jen, H Li… - Oncology …, 2011 - spandidos-publications.com
Breast cancer and obesity are serious health problems and their relationship has been
studied for many years. Leptin is mainly secreted by adipocytes and plays a key role in …

[HTML][HTML] Zeranol stimulates proliferation and aromatase activation in human breast preadipocytes

S Zhong, S Liu, S Chen, H Lin… - Molecular Medicine …, 2016 - spandidos-publications.com
Aromatase is a crucial enzyme for the biosynthesis of estrogens and is involved in the
process of breast carcinogenesis. Concerns have been raised regarding the effects of …

Leptin and zeranol up-regulate cyclin D1 expression in primary cultured normal human breast pre-adipocytes

P Xu, W Ye, S Zhong, H Li, E Feng… - Molecular …, 2010 - spandidos-publications.com
Adipocytes account for more than 90% of human breast volume and secrete adipocytokines,
which play a role in breast cancer development. Among the adipocytokines is leptin, which …

Serum derived from zeranol-implanted ACI rats promotes the growth of human breast cancer cells in vitro

S Zhong, WP Ye, E Feng, SH Lin, JY Liu… - Anticancer …, 2011 - ar.iiarjournals.org
Background: Zeranol (Z) is a non-steroidal anabolic growth promoter with potent estrogenic
activity that is widely used as a growth promoter in the US beef industry. Consumption of …

In vitro transformation of MCF-10A cells by sera harvested from heifers two months post-Zeranol implantation

W Ye, P Xu, S Zhong, R Jen… - International …, 2011 - spandidos-publications.com
Among many risk factors of breast cancer, estrogens and non-estrogenic endocrine
disruptors are considered to play critical roles in human breast carcinogenesis. Zeranol (Z) …

NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin–aromatase interactions

LW Bowers, IXF Maximo, AJ Brenner, M Beeram… - Cancer research, 2014 - AACR
Obesity is associated with a worse breast cancer prognosis and elevated levels of
inflammation, including greater cyclooxygenase-2 (COX-2) expression and activity in …

Zeranol enhances the proliferation of pre-adipocytes in beef heifers

W Ye, P Xu, WR Threlfall, R Jen, H Li, SH Lin… - Anticancer …, 2009 - ar.iiarjournals.org
Background: The high morbidity and mortality of breast cancer among women is a serious
problem. The adverse effects of the consumption of beef with zeranol (Z, a growth promoter …