Background/Aim: CC motif chemokine ligand 18 (CCL18) is overexpressed in the
microenvironment of tumors, promotes invasion and metastasis and is thus important for the …

Background Chemokine (CXC motif) ligand 17 (CXCL17) is the latest member of the
chemokine family. However, its function in various cancer types is unknown. The G protein …

CCR10, a member of the chemokine receptor subfamily, is overexpressed in several tumors
and play a crucial role in cancer development and progression. However, the functions of …

CC chemokine receptor type 7 (CCR7) is involved in the development and progressions of
chronic inflammatory diseases and cancer; therefore, signaling pathways that regulate …

Estrogens are structurally related steroids that regulate important physiological processes.
17β-estradiol (E2) is reversibly oxidized to estrone (E1) and both E2 and E1 can be …

Cancer is currently one of the leading causes of death worldwide and is one of the most
challenging major public health problems. The main challenges faced by clinicians in the …

Background Recent advances have revealed a significant contribution of chemokines and
their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis …

Background The activation of the EGFR/Ras-signalling pathway in tumour cells induces a
distinct chemokine repertoire, which in turn modulates the tumour microenvironment …

Chemokines constitute a superfamily of small chemotactic cytokines with functions that are
based on interactions with their corresponding receptors. It has been found that, among …

Background Due to the lack of ERα, triple negative breast cancers (TNBCs) are not
susceptible to endocrine therapy using antiestrogens. However, the majority of TNBCs …