β-elemene effectively suppresses the growth and survival of both platinum-sensitive and-resistant ovarian tumor cells

RX Lee, QQ Li, E Reed - Anticancer research, 2012 - ar.iiarjournals.org
The development of cisplatin drug resistance remains a chief concern in ovarian cancer
chemotherapy. β-Elemene is a natural plant product with broad-spectrum antitumor activity …

[HTML][HTML] β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK

QQ Li, RX Lee, H Liang, G Wang… - International …, 2013 - spandidos-publications.com
Abstract β-Elemene is a promising new plant-derived drug with broad-spectrum anticancer
activity. It also increases cisplatin cytotoxicity and enhances cisplatin sensitivity in resistant …

Antiproliferative effect of β-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase

X Li, G Wang, J Zhao, H Ding, C Cunningham… - Cellular and Molecular …, 2005 - Springer
Elemene is a natural antitumor plant drug. However, the effect of elemene on cell growth in
ovarian cancer is unknown. In this study, we show that β-elemene inhibited the proliferation …

Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells

QQ Li, RX Lee, H Liang, Y Zhong, E Reed - Medical oncology, 2013 - Springer
Abstract β-Elemene is a new anticancer compound extracted from the Chinese medicinal
herb Rhizoma zedoariae. We have shown previously that β-elemene increases cisplatin …

β-elemene and taxanes synergistically induce cytotoxicity and inhibit proliferation in ovarian cancer and other tumor cells

B Zou, QQ Li, J Zhao, JM Li, CF Cuff… - Anticancer research, 2013 - ar.iiarjournals.org
β-Elemene, originally derived from plants, has been recently investigated as a new
anticancer agent. The purpose of this study was to explore the efficacy and mechanisms of …

β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas

QQ Li, G Wang, H Liang, JM Li, F Huang… - Anticancer …, 2013 - ar.iiarjournals.org
Cisplatin-based combination treatment is the most effective systemic chemotherapy for
bladder cancer; however, resistance to cisplatin remains a significant problem in the …

Antineoplastic effect of β-elemene on prostate cancer cells and other types of solid tumour cells

QQ Li, G Wang, F Huang, M Banda… - Journal of Pharmacy …, 2010 - academic.oup.com
Objectives β-Elemene, a natural compound extracted from over 50 different Chinese
medicinal herbs and plants, has been effective in the treatment of hyperplastic and …

Evaluation of Cisplatin in Combination with β‐Elemene as a Regimen for Prostate Cancer Chemotherapy

QQ Li, G Wang, E Reed, L Huang… - Basic & clinical …, 2010 - Wiley Online Library
Cisplatin is one of the most potent chemotherapeutic agents for the treatment of many types
of solid tumours. Nevertheless, it is not the first‐line drug for prostate cancer chemotherapy …

β-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis

QQ Li, G Wang, M Zhang, CF Cuff… - Oncology …, 2009 - spandidos-publications.com
Abstract β-Elemene, a new plant-derived anticancer agent with low toxicity, has been
reported to be effective in the treatment of leukemia and solid tumors. In the current study …

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic …

QQ Li, G Wang, F Huang, JM Li, CF Cuff, E Reed - Medical Oncology, 2013 - Springer
The development of effective agents for overcoming platinum chemoresistance in lung
carcinoma continues to have high priority. We have demonstrated recently that β-elemene, a …