Prostate cancer and inositol hexaphosphate: efficacy and mechanisms

RP Singh, R Agarwal - Anticancer research, 2005 - ar.iiarjournals.org
There are now extensive scientific data suggesting the potential role of dietary and non-
dietary phytochemicals in the prevention and control of prostate cancer (PCA) growth and …

Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells

G Sharma, RP Singh… - … journal of oncology, 2003 - spandidos-publications.com
Abstract Inositol hexaphosphate (IP6), a dietary agent, has been extensively studied for its
cancer chemopreventive and anti-cancer efficacy in several different animal models, but not …

Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice

K Raina, S Rajamanickam, RP Singh, R Agarwal - Clinical Cancer Research, 2008 - AACR
Purpose: Herein, for the first time, we evaluated the in vivo chemopreventive efficacy of
inositol hexaphosphate (IP6), a major constituent of high-fiber diets, against prostate tumor …

Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells

C Agarwal, S Dhanalakshmi, RP Singh, R Agarwal - Neoplasia, 2004 - Elsevier
Prostate cancer (PCA) is the most common invasive malignancy and the second leading
cause of cancerrelated deaths in the US male population. One approach to control this …

Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb …

RP Singh, C Agarwal, R Agarwal - Carcinogenesis, 2003 - academic.oup.com
Cancer chemopreventive effects of inositol hexaphosphate (IP6), a dietary constituent, have
been demonstrated against a variety of experimental tumors, however, limited studies have …

Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells

AM Shamsuddin, GY Yang - Carcinogenesis, 1995 - academic.oup.com
We investigated the effects of inositol hexaphosphate (InsP6) on growth inhibition and
differentiation of human prostate cancer cells PC-3 in vitro. A significant dose-and time …

In Vivo Suppression of Hormone-Refractory Prostate Cancer Growth by Inositol Hexaphosphate: Induction of Insulin-Like Growth Factor Binding Protein …

RP Singh, G Sharma, GU Mallikarjuna… - Clinical Cancer …, 2004 - AACR
Purpose: Diet composition is an important etiologic factor in prostate cancer (PCA) growth
and has significant impact on clinical PCA appearance. Because inositol hexaphosphate …

Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential …

M Gu, S Roy, K Raina, C Agarwal, R Agarwal - Cancer research, 2009 - AACR
Constitutive activation of phosphoinositide 3-kinase (PI3K)-Akt pathway transmits growth-
regulatory signals that play a central role in promoting survival, proliferation, and …

Protection Against Cancer by Dietary IP6 and Inositol

I Vucenik, AKM Shamsuddin - Nutrition and cancer, 2006 - Taylor & Francis
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate,
abundantly present in many plant sources and in certain high-fiber diets, such as cereals …

[HTML][HTML] Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic

I Vucenik, AKM Shamsuddin - The Journal of nutrition, 2003 - Elsevier
Inositol hexaphosphate (IP 6) is a naturally occurring polyphosphorylated carbohydrate that
is present in substantial amounts in almost all plant and mammalian cells. It was recently …