Maturation of tumor vasculature by interferon-β disrupts the vascular niche of glioma stem cells

RF Williams, TL Sims, L Tracey, AL Myers… - Anticancer …, 2010 - ar.iiarjournals.org
Background: The vascular niche necessary for cancer stem cell maintenance is a potential
target for cancer therapy. Materials and Methods: Human glioma xenografts were treated …

Neural progenitor cell-mediated delivery of interferon beta improves neuroblastoma response to cyclophosphamide

TL Sims, JB Hamner, RA Bush, RF Williams… - Annals of surgical …, 2008 - Springer
Background We have shown that continuous systemic delivery of interferon beta (IFN-β)
remodels dysfunctional tumor vasculature, thereby improving tumor perfusion and …

Continuous delivery of IFN-β promotes sustained maturation of intratumoral vasculature

PV Dickson, JB Hamner, CJ Streck, CYC Ng… - Molecular cancer …, 2007 - AACR
IFNs have pleiotropic antitumor mechanisms of action. The purpose of this study was to
further investigate the effects of IFN-β on the vasculature of human xenografts in …

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche

DW Infanger, YJ Cho, BS Lopez, S Mohanan, SC Liu… - Cancer research, 2013 - AACR
Glioblastoma multiforme contains a subpopulation of cancer stem–like cells (CSC) believed
to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs …

Endothelial cell-based cytokine gene delivery inhibits 9L glioma growth in vivo

M Nam, P Johnston, B Lal, R Indurti, MA Wilson… - Brain research, 1996 - Elsevier
Malignant brain neoplasms present great therapeutic challenges due to their extremely
aggressive behavior and relative isolation by the blood-brain and blood-tumor barriers …

[HTML][HTML] Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Q Wang, Z He, M Huang, T Liu, Y Wang, H Xu… - Nature …, 2018 - nature.com
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a
vascular niche that controls alternative macrophage activation in glioblastoma (GBM). We …

[HTML][HTML] Endothelial cells promote 3D invasion of GBM by IL-8-dependent induction of cancer stem cell properties

MG McCoy, D Nyanyo, CK Hung, JP Goerger… - Scientific reports, 2019 - nature.com
Rapid growth and perivascular invasion are hallmarks of glioblastoma (GBM) that have
been attributed to the presence of cancer stem-like cells (CSCs) and their association with …

Continuous local delivery of interferon-β stabilizes tumor vasculature in an orthotopic glioblastoma xenograft resection model

JW Denbo, RF Williams, WS Orr, TL Sims, CY Ng… - Surgery, 2011 - Elsevier
BACKGROUND: High-grade glioblastomas have immature, leaky tumor blood vessels that
impede the efficacy of adjuvant therapy. We assessed the ability of human interferon (hIFN) …

[HTML][HTML] A perivascular niche for brain tumor stem cells

C Calabrese, H Poppleton, M Kocak, TL Hogg, C Fuller… - Cancer cell, 2007 - cell.com
Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells
remain dependent upon the niche microenvironments that regulate normal stem cells. We …

Bone marrow-derived mesenchymal stem cells as vehicles for interferon-β delivery into tumors

M Studeny, FC Marini, RE Champlin, C Zompetta… - Cancer research, 2002 - AACR
Molecules that physiologically control cell proliferation are often produced locally in tissues
and are rapidly destroyed when they enter circulation. This allows local effects while …