Reliability of direct sequencing of EGFR: comparison between cytological and histological samples from the same patient

P Bruno, S Mariotta, A Ricci, E Duranti… - Anticancer …, 2011 - ar.iiarjournals.org
The results of a recent study have shown the superiority of treatment with gefitinib or erlotinib
in lung tumors positive for epidermal growth factor receptor (EGFR) mutation. As a …

[HTML][HTML] A new rapid method for detecting epidermal growth factor receptor mutations in non-small cell lung cancer

M Takata, H Chikumi, K Matsunami… - Oncology …, 2015 - spandidos-publications.com
Mutations in the epidermal growth factor receptor (EGFR) gene are associated with a
favorable clinical response to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib in …

Detection of Common and Less Frequent EGFR Mutations in Cytological Samples of Lung Cancer

ED Rossi, R Gerhard, L Cirnes, JC Machado… - Acta Cytologica, 2014 - karger.com
Objective: Lung cancer represents the leading cause of cancer death. EGFR mutations,
detected in 10-40% of lung adenocarcinomas, are an essential key to therapeutic …

A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer

Y Yatabe, T Hida, Y Horio, T Kosaka… - The Journal of Molecular …, 2006 - Elsevier
It has been demonstrated that lung cancers, specifically a subset of pulmonary
adenocarcinomas, with epidermal growth factor receptor (EGFR) mutation are highly …

[HTML][HTML] Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays

B Weber, P Meldgaard, H Hager, L Wu, W Wei, J Tsai… - BMC cancer, 2014 - Springer
Background Lung cancer patients with mutations in the epidermal growth factor receptor
(EGFR) are primary candidates for EGFR-targeted therapy. Reliable analyses of such …

Routine EGFR Molecular Analysis in Non-Small-Cell Lung Cancer Patients is Feasible: Exons 18–21 Sequencing Results of 753 Patients and Subsequent Clinical …

M Locatelli-Sanchez, S Couraud, D Arpin, R Riou… - Lung, 2013 - Springer
Background Epidermal growth factor receptor (EGFR)-targeting therapies dramatically
modified the prognosis of stage 4 non-small-cell lung cancer. Sensitizing EGFR mutations …

[HTML][HTML] Application of PCR methods to evaluate EGFR, KRAS and BRAF mutations in a small number of tumor cells in cytological material from lung cancer patients

MA Lewandowska, W Jóźwicki… - Oncology …, 2013 - spandidos-publications.com
The epidermal growth factor receptor (EGFR) mutation status in the tyrosine kinase domain
is known to be a predictor of the response to gefitinib or erlotinib in lung cancer; thus, a non …

EGFR mutation testing in pulmonary adenocarcinoma: evaluation of tumor cell number and tumor percent in paraffin sections of 120 small biopsies

S Scarpino, F Pulcini, A Di Napoli, M Giubettini, L Ruco - Lung Cancer, 2015 - Elsevier
Objectives Successful evaluation of EGFR mutational status in small biopsies may be
hampered by the number of tumor cells present in the tissue section. The aim of the present …

Accuracy of epidermal growth factor receptor gene mutation analysis by direct sequencing method based on small biopsy specimens from patients with non-small cell …

K Masago, S Fujita, T Mio, M Ichikawa… - International journal of …, 2008 - Springer
Background The importance of an epidermal growth factor receptor (EGFR) gene mutation
has been recognized in patients with non-small cell lung cancer (NSCLC), and many reports …

Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma

EF Brachtel, AJ Iafrate, EJ Mark… - Diagnostic …, 2007 - Wiley Online Library
The initial diagnosis of lung carcinoma is frequently made by fine‐needle aspiration biopsy.
Novel therapeutic strategies of this disease include tyrosine kinase inhibitors (TKI), such as …