PDK1 is expressed in ovarian serous carcinoma and correlates with improved survival in high-grade tumors

P Lohneis, S Darb-Esfahani, M Dietel, I Braicu… - Anticancer …, 2015 - ar.iiarjournals.org
Background/Aim: 3-Phosphoinositide-dependent protein kinase-1 (PDK1) mediates the
cellular effects of various growth factors. Increased PDK1 expression is present in various …

[HTML][HTML] The oncogenic and prognostic role of PDK1 in the progression and metastasis of ovarian cancer

S Yao, W Shang, L Huang, R Xu, M Wu… - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Ovarian cancer (OC) is the most lethal of gynecological tumors in women. Tumor
metabolism has become a new opportunity in the treatment of tumors. Pyruvate …

Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer

J Wang, Y Qian, M Gao - Cancer Management and Research, 2018 - Taylor & Francis
Purpose Ovarian cancer is a major type of gynecological malignancy which characterized by
the chemoresistance, heterogeneity and highly metastasis. However, the mechanism …

[HTML][HTML] PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling

MKY Siu, Y Jiang, J Wang, THY Leung, SF Ngu… - Oncogenesis, 2020 - nature.com
Ovarian cancer is the most lethal gynecological malignancies owing to the lack of definitive
symptoms until development of widespread metastases. Identification of novel prognostic …

Upregulation of PDK1 associates with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro

Z Yang, Z Wu, T Liu, L Han, C Wang, B Yang, F Zheng - Medical oncology, 2014 - Springer
Phosphoinositide-dependent protein kinase-1 (PDK1) has been reported to be closely
correlated with proliferation, apoptosis and invasion of esophageal cancer cells. However …

The expression of CDK1 is associated with proliferation and can be a prognostic factor in epithelial ovarian cancer

Q Xi, M Huang, Y Wang, J Zhong, R Liu, G Xu, L Jiang… - Tumor Biology, 2015 - Springer
Overexpression of cyclin-dependent kinase 1 (CDK1) has been noted to correlation with
several human cancers. However, the effects of CDK1 on ovarian cancer development …

[HTML][HTML] Loss of PDK4 expression promotes proliferation, tumorigenicity, motility and invasion of hepatocellular carcinoma cells

YJ Qin, TY Lin, XL Lin, Y Liu, WT Zhao, XY Li… - Journal of …, 2020 - ncbi.nlm.nih.gov
Although the roles and underlying mechanisms of other PDK family members (ie, PDK1,
PDK2 and PDK3) in tumor progression have been extensively investigated and are well …

Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1

JJ Wang, MK Siu, YX Jiang, TH Leung, DW Chan… - …, 2019 - Taylor & Francis
Blockade of the programmed cell death 1 (PD-1)/PD-1 ligand-1 (PD-L1) pathway has been
exploited therapeutically in many cancer types. Upregulation of PD-L1 in tumor cells …

Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target

X Zhang, Z Yu - Clinical and Translational Oncology, 2019 - Springer
Purpose Phosphoinositide-dependent kinase 1 (PDK1) is highly expressed in many solid
tumors. And several studies have demonstrated that PDK1 has been an emerging and …

Correlation of PDK1 expression with clinicopathologic features and prognosis of hepatocellular carcinoma

J Wang, F Liu, P Ao, X Li, H Zheng, D Wu… - OncoTargets and …, 2016 - Taylor & Francis
Objective To explore the clinical significance of 3-phosphoinositide-dependent protein
kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with …