Background/Aim: Protein kinase CK2 was recently identified as a promising therapeutic
target for combination therapy. Our study aims to investigate the anticancer effect of a …

Background/Aim: Recently, we demonstrated the ability of inhibitors of protein kinase 2
(casein kinase II; CK2) to enhance the efficacy of 5-fluorouracil, a thymidylate synthase …

Thymidylate synthase (TS), dihydrofolate reductase (DHFR), and serine
hydroxymethyltransferase (SHMT) constitute the thymidylate synthesis cycle providing …

Background: Casein kinase-2 (CK2) inhibitors and pentabromobenzylisothioureas are
promising anti-leukemic agents for treatment, both alone and in combination. In this study …

Background: The combination effect of 5-fluorouracil (5-FU) with either CX-4945 or a new
inhibitor of protein kinase CK2, namely 14B (4, 5, 6, 7-tetrabromo-1-(3-bromopropyl)-2 …

BACKGROUND: Abnormally high activity of protein kinase CK2 is linked to various diseases
including cancer. Therefore, the inhibition of CK2 is a promising therapeutic strategy to fight …

Malignant gliomas are highly resistant to current therapeutic approaches due to genetic
alterations rendering them resistant to cell death. CK2, a ubiquitous and constitutively active …

Abstract Protein kinase CK2 (CK2) is a highly conserved and ubiquitous serine/threonine
kinase. It is a multifunctional and pleiotropic protein kinase implicated in the regulation of …

Human protein kinase CK2 is an important target for the development of anticancer drugs.
Many inhibitors were developed in the last few decades, among them emodin, a natural …

Besides cardiovascular diseases, cancer represents the major cause of death in developed
countries. In many different human tumors, increased activity of serine/threonine protein …