Minodronic Acid in Combination with γδT Cells Induces Apoptosis of Non-small Cell Lung Carcinoma Cell Lines

M Yasukawa, T Nakazawa, T Kawaguchi… - Anticancer …, 2016 - ar.iiarjournals.org
Background/Aim: Non-small cell lung carcinoma (NSCLC) is one of the leading causes of
cancer-related death worldwide. Recent studies showed that nitrogen-containing …

Anti-cancer effects of bisphosphonates in lung cancer cell lines

CD MacDonald, LM Pickering, JL Mansi… - Journal of Clinical …, 2004 - ascopubs.org
7289 Background: Lung carcinoma is one of the most commonly diagnosed cancers
worldwide and systemic spread of the primary tumour is common: 80% of lung cancers …

Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vγ9Vδ2 T cells

S Dhar, SV Chiplunkar - Cancer immunity, 2010 - AACR
Aminobisphosphonates are drugs administered for the treatment of bone resorption. They
can indirectly activate peripheral γδ T cells and render tumor cells susceptible to lysis by …

[PDF][PDF] Cytotoxic function of gamma delta (gamma/delta) T cells against pamidronate-treated cervical cancer cells

M Lertworapreecha, S Patumraj, S Niruthisard… - Indian J Exp …, 2013 - academia.edu
The cytotoxic function of polyclonal expanded γ/δ T cells against pamidronate-treated
cervical cancer cells in vitro and in vivo were determined. The γ/δ T cells were isolated and …

Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by bcl-2

N Schrantz, DA Blanchard, F Mitenne… - Cell Death & …, 1999 - nature.com
Manganese ions block apoptosis of phagocytes induced by various agents. The prevention
of apoptosis was attributed to the activation of manganous superoxide dismutase (Mn-SOD) …

Effects of bisphosphonates on proliferation of lung cancer cells in vitro

X Lin, H Yu, C Tan, B Chen, T Wang… - Zhongguo fei ai za zhi …, 2005 - europepmc.org
Background Bisphosphonates have been used to treat many bone diseases in clinic.
Bisphosphonates have also been proven useful in the management of bone metastasis in …

[HTML][HTML] The antineoplastic role of bisphosphonates: from basic research to clinical evidence

D Santini, UV Gentilucci, B Vincenzi, A Picardi… - Annals of …, 2003 - Elsevier
Bisphosphonates are now well established as successful agents for the prevention and
treatment of postmenopausal osteoporosis, corticosteroid-induced bone loss and Paget's …

[HTML][HTML] Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines

R Koshimune, M Aoe, S Toyooka, F Hara, M Ouchida… - BMC cancer, 2007 - Springer
Background YM529 is a newly developed nitrogen-containing bisphosphonate (BP)
classified as a third-generation BP that shows a 100-fold greater potency against bone …

Cytotoxic effects of γδ T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy

K Sato, S Kimura, H Segawa, A Yokota… - … journal of cancer, 2005 - Wiley Online Library
Nitrogen containing‐bisphosphonates (N‐BPs), widely used to treat bone diseases, have
direct antitumor effects via the inactivation of Ras proteins. In addition to the direct antitumor …

Zoledronic acid inhibits cancer growth and cancer stem cell phenotypes in head and neck squamous cell carcinoma.

SH Lee, R Kim, M Kang, NH Park, KH Shin - Cancer Research, 2013 - AACR
Zoledronic acid (ZA), a third generation of bisphosphonates, is known to have both anti-
osteolytic and anti-tumor activities. It exerts anti-osteolytic function by interfering with …