Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway
MR Sadaria, JA Yu, X Meng, DA Fullerton… - Anticancer …, 2013 - ar.iiarjournals.org
Background/Aim: Secretory phospholipase-A2 (sPLA2) mediates growth and proliferation of
human esophageal adenocarcinoma cells (HEAC). Two major molecular pathways of …
human esophageal adenocarcinoma cells (HEAC). Two major molecular pathways of …
Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma
AL Halpern, PD Kohtz, AM White, AK Houk… - Digestive diseases and …, 2021 - Springer
Background Receptor tyrosine kinases of the epidermal growth factor receptor (EGFR)
family such as human epidermal receptor-2 (HER2) are involved in the development and …
family such as human epidermal receptor-2 (HER2) are involved in the development and …
[HTML][HTML] Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A2
D Mauchley, X Meng, T Johnson, DA Fullerton… - The Journal of thoracic …, 2010 - Elsevier
OBJECTIVE: Esophageal adenocarcinoma is thought to arise from lesions produced by
chronic esophageal inflammation. Secretory phospholipase A2 is an important mediator of …
chronic esophageal inflammation. Secretory phospholipase A2 is an important mediator of …
Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A2 inhibitor
Y Xie, Z Yu, L Liu, Y Guo, L Lou - Cancer biology & therapy, 2006 - Taylor & Francis
The marine natural product scalaradial (SLD) is a potent inhibitor of secretory
phospholipase A2 (sPLA2). Our previous work has demonstrated that SLD inhibits …
phospholipase A2 (sPLA2). Our previous work has demonstrated that SLD inhibits …
Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells
MR Sadaria, X Meng, DA Fullerton, TB Reece… - The Annals of thoracic …, 2011 - Elsevier
Background Esophageal adenocarcinoma is an aggressive malignancy, with most patients
succumbing to metastatic disease. The presence of intercellular adhesion molecule-1 (ICAM …
succumbing to metastatic disease. The presence of intercellular adhesion molecule-1 (ICAM …
[HTML][HTML] Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells
Z Dong, J Meller, P Succop… - International …, 2014 - spandidos-publications.com
Lung cancer is the leading cause of cancer death worldwide. There is an urgent need for
early diagnostic tools and novel therapies in order to increase lung cancer survival …
early diagnostic tools and novel therapies in order to increase lung cancer survival …
Secretory phospholipase A2 inhibits epidermal growth factor-induced receptor activation
S Zhao, XY Du, JS Chen, YC Zhou, JG Song - Experimental cell research, 2002 - Elsevier
Secretory phospholipase A2 (sPLA2) plays important roles in mediating various cellular
processes, including cell proliferation, differentiation, apoptosis, and inflammatory response …
processes, including cell proliferation, differentiation, apoptosis, and inflammatory response …
Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth
GS Belinsky, TV Rajan, EA Saria… - … in cooperation with …, 2007 - Wiley Online Library
Abstract Secretory phospholipase A2 (sPLA2‐IIA) has been shown to attenuate intestinal
tumorigenesis in ApcMin mice, demonstrating that it is a tumor modifier. To further explore …
tumorigenesis in ApcMin mice, demonstrating that it is a tumor modifier. To further explore …
[HTML][HTML] Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo
AY Jessica, D Mauchley, H Li, X Meng… - The Journal of thoracic …, 2012 - Elsevier
OBJECTIVE: Group IIa secretory phospholipase A2 (sPLA2 IIa) plays a role in the malignant
potential of several epithelial cancers. Nuclear factor kappa B (NF-κB) regulates cancer cell …
potential of several epithelial cancers. Nuclear factor kappa B (NF-κB) regulates cancer cell …
[HTML][HTML] Expression of secreted phospholipase A2-Group IIA correlates with prognosis of gastric adenocarcinoma
C Zhang, H Yu, H Xu, L Yang - Oncology Letters, 2015 - spandidos-publications.com
The present study investigated the expression of secretory phospholipase A2-Group IIA
(sPLA2-II) in gastric adenocarcinoma, in order to evaluate the correlation between sPLA2-II …
(sPLA2-II) in gastric adenocarcinoma, in order to evaluate the correlation between sPLA2-II …