Serum detection of thymidine kinase 1 as a means of early detection of lung cancer
MM Alegre, MJ Weyant, DT Bennett, JA Yu… - Anticancer …, 2014 - ar.iiarjournals.org
Background: Thymidine kinase 1 (TK1) is a biomarker elevated in several malignancies,
including lung cancer. Up-regulation of TK1 is an early event in carcinogenesis and …
including lung cancer. Up-regulation of TK1 is an early event in carcinogenesis and …
Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer
HX Li, DS Lei, XQ Wang, S Skog… - Oncology …, 2005 - spandidos-publications.com
Abstract Thymidine kinase 1 (TK1) is a pyrimidine metabolic pathway enzyme involved in
salvage DNA synthesis and thus, a cell cycle-dependent marker. We have developed anti …
salvage DNA synthesis and thus, a cell cycle-dependent marker. We have developed anti …
[HTML][HTML] Serum thymidine kinase 1 activity in the prognosis and monitoring of chemotherapy in lung cancer patients: a brief report
B Nisman, H Nechushtan, H Biran… - Journal of Thoracic …, 2014 - Elsevier
Introduction Thymidine kinase 1 (TK1) is a metabolic enzyme involved in DNA synthesis.
Most standard treatment protocols for lung cancer (LC) include cytotoxic agents, which are …
Most standard treatment protocols for lung cancer (LC) include cytotoxic agents, which are …
[PDF][PDF] Thymidine kinase 1: a universal marker for cancer
MM Alegre, RA Robison, KL O'Neill - Cancer Clin Oncol, 2013 - pdfs.semanticscholar.org
Abstract Thymidine Kinase 1 (TK1) is traditionally a serum biomarker which is elevated in
the early stages of malignancies. TK1 is a DNA repair enzyme which is typically associated …
the early stages of malignancies. TK1 is a DNA repair enzyme which is typically associated …
Clinical relevance of Thymidine Kinase for the diagnosis, therapy monitoring and prognosis of non-οperable lung cancer
S Holdenrieder, J Von Pawel, T Duell… - Anticancer …, 2010 - ar.iiarjournals.org
Background: Whether thymidine kinase (TK) is considered a new diagnostic biomarker in
lung cancer depends on it being superior to or adding further information to already …
lung cancer depends on it being superior to or adding further information to already …
Thymidine kinase 1 as a tumor biomarker: technical advances offer new potential to an old biomarker
KK Jagarlamudi, M Shaw - Biomarkers in medicine, 2018 - Future Medicine
Thymidine kinase 1 (TK1) is a key enzyme in DNA precursor synthesis. It is upregulated
during the S phase of the cell cycle and its presence in cells is an indicator of active cell …
during the S phase of the cell cycle and its presence in cells is an indicator of active cell …
Expression of cell proliferating genes in patients with non-small cell lung cancer by immunohistochemistry and cDNA profiling
Y Mao, J Wu, S Skog, S Eriksson… - Oncology …, 2005 - spandidos-publications.com
Abstract Thymidine kinase 1 (TK1) is a key enzyme involved in the synthesis of DNA
precursors and thus, cell proliferation-dependent. Antibodies against TK1 have provided …
precursors and thus, cell proliferation-dependent. Antibodies against TK1 have provided …
[HTML][HTML] Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies
EG Weagel, W Burrup, R Kovtun, EJ Velazquez… - Cancer Cell …, 2018 - Springer
Background Lung, breast, and colorectal malignancies are the leading cause of cancer-
related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite …
related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite …
[HTML][HTML] Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma
Y Ji, XB Wu, JY Chen, B Hu, QK Zhu… - … Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Patients with esophageal cancer are often diagnosed at advanced stages, leading to poor
prognosis. Biomarkers are needed to enable earlier detection as well as to aid in the …
prognosis. Biomarkers are needed to enable earlier detection as well as to aid in the …
Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer
Context: TK1 found to be elevated biomarker in many solid cancers. Objectives: The study
aimed to assess the prognostic significance of a serum TK1 in patients with metastatic …
aimed to assess the prognostic significance of a serum TK1 in patients with metastatic …
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