Elevated Neutrophil–to–lymphocyte-ratio and platelet–to–lymphocyte ratio in myelofibrosis: Inflammatory biomarkers or representatives of myeloproliferation itself?
Background/Aim: We aimed to investigate clinical associations of inflammatory biomarkers
neutrophil-to-lymphocyte-ratio (NLR) and platelet-to-lymphocyte-ratio (PLR) in patients with …
neutrophil-to-lymphocyte-ratio (NLR) and platelet-to-lymphocyte-ratio (PLR) in patients with …
[HTML][HTML] Systemic inflammatory indices for predicting prognosis of myelofibrosis
The impact of inflammatory markers such as systemic immune-inflammation (SII) index and
systemic inflammation response index (SIRI) on myelofibrosis (MF) prognosis was evaluated …
systemic inflammation response index (SIRI) on myelofibrosis (MF) prognosis was evaluated …
Clinical correlates and prognostic significance of IL-8, sIL-2R, and immunoglobulin-free light chain levels in patients with myelofibrosis
MV Barabanshikova, IA Dubina, SV Lapin… - Oncology Research …, 2017 - karger.com
Background: Chronic myeloproliferative neoplasms are characterized by clonal
hematopoiesis and persistent inflammatory reaction. In this study, the clinical significance …
hematopoiesis and persistent inflammatory reaction. In this study, the clinical significance …
[HTML][HTML] Circulating cytokine levels as markers of inflammation in Philadelphia negative myeloproliferative neoplasms: diagnostic and prognostic interest
J Mondet, K Hussein, P Mossuz - Mediators of inflammation, 2015 - hindawi.com
Cytokines are well known mediators of numerous physiological and pathological processes.
They contribute to the regulation of normal hematopoiesis but increasing data suggest that …
They contribute to the regulation of normal hematopoiesis but increasing data suggest that …
[PDF][PDF] Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study
Purpose Abnormal cytokine expression accompanies myelofibrosis and might be a
therapeutic target for Janus-associated kinase (JAK) inhibitor drugs. This study describes …
therapeutic target for Janus-associated kinase (JAK) inhibitor drugs. This study describes …
[HTML][HTML] Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
MC Cacemiro, JG Cominal, R Tognon… - … , transfusion and cell …, 2018 - SciELO Brasil
Background: Cytokines are key immune mediators in physiological and disease processes,
whose increased levels have been associated with the physiopathology of hematopoietic …
whose increased levels have been associated with the physiopathology of hematopoietic …
Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosis
Myelofibrosis (MF) is a stem cell-derived neoplasm encompassing one of the chronic
myeloproliferative neoplasms (MPN), and may present as primary (PMF) or secondary to …
myeloproliferative neoplasms (MPN), and may present as primary (PMF) or secondary to …
Assessing serum albumin concentration, lymphocyte count and prognostic nutritional index might improve prognostication in patients with myelofibrosis
Background Primary and secondary myelofibrosis (PMF and SMF) are malignant diseases
of hematopoietic stem cell characterized by the neoplastic myeloproliferation and a strong …
of hematopoietic stem cell characterized by the neoplastic myeloproliferation and a strong …
Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling
DAC Fisher, CA Miner, EK Engle, H Hu, TB Collins… - Leukemia, 2019 - nature.com
The distinct clinical features of myelofibrosis (MF) have been attributed in part to
dysregulated inflammatory cytokine production. Circulating cytokine levels are elevated in …
dysregulated inflammatory cytokine production. Circulating cytokine levels are elevated in …
[HTML][HTML] Cytokine profile changes in 309 myelofibrosis patients: comparison Of JAK1/JAK2 inhibitor therapy vs. placebo–correlative analysis from the Comfort-I trial
AC Dueck, CS Cleeland, R Dantzer, J Sloan… - Blood, 2013 - Elsevier
Background Inflammatory deregulation may be a major factor in cancer related symptoms
(Dantzer Nature Rev Clin Oncol 2012). Improved symptoms in myelofibrosis (MF) patients …
(Dantzer Nature Rev Clin Oncol 2012). Improved symptoms in myelofibrosis (MF) patients …
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