Subcellular localization of maspin correlates with histone deacetylase 1 expression in human breast cancer

M Wakahara, T Sakabe, Y Kubouchi… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: Maspin is known to be a tumor suppressor protein. Its nuclear localization
and endogenous inhibition of histone deacetylase 1 (HDAC1) are considered crucial for its …

[HTML][HTML] Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells

M Machowska, K Wachowicz, M Sopel, R Rzepecki - BMC cancer, 2014 - Springer
Background Maspin, which is classified as a tumor suppressor protein, is downregulated in
many types of cancer. Several studies have suggested potential anti-proliferative activity of …

Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin

X Li, S Yin, Y Meng, W Sakr, S Sheng - Cancer research, 2006 - AACR
Maspin, a noninhibitory serine protease inhibitor, exerts multifaceted tumor-suppressive
effects. Maspin expression is associated with better differentiated phenotypes, better cancer …

Down regulation of the tumor suppressor gene maspin in breast carcinoma is associated with a higher risk of distant metastasis

N Maass, T Hojo, F Rösel, T Ikeda, W Jonat… - Clinical …, 2001 - Elsevier
Background: Maspin (mammary serpin) is a relatively novel serine protease inhibitor with
tumor suppressing function in breast cancer. Maspin expression was found in normal breast …

Maspin Expression Profile in Human Prostate Cancer (CaP) and in Vitro Induction of Maspin Expression by Androgen Ablation

Z Zou, W Zhang, D Young, MG Gleave, P Rennie… - Clinical cancer …, 2002 - AACR
Purpose: Expression of tumor suppressor gene, MASPIN, is associated with inhibition of
tumor cell invasion and metastasis. Loss of or decreased expression of Maspin is found …

[HTML][HTML] Identification of an intrinsic determinant critical for maspin subcellular localization and function

SH Dzinic, A Kaplun, X Li, M Bernardo, Y Meng, I Dean… - PloS one, 2013 - journals.plos.org
Maspin, a multifaceted tumor suppressor, belongs to the serine protease inhibitor
superfamily, but only inhibits serine protease-like enzymes such as histone deacetylase 1 …

Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer

E Shankar, M Pandey, S Verma, A Abbas… - Molecular …, 2020 - Wiley Online Library
Maspin repression is frequently observed in prostate cancer; however, the molecular
mechanism (s) causing the loss is not completely understood. Here, we demonstrate that …

Epigenetic silencing of maspin gene expression in human breast cancers

FE Domann, JC Rice, MJC Hendrix… - … journal of cancer, 2000 - Wiley Online Library
Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers.
Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise …

Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer

N Maass, M Biallek, F Rösel, C Schem, N Ohike… - Biochemical and …, 2002 - Elsevier
Maspin is a member of the serine protease inhibitor family with tumor suppressing activity in
breast cancer. Maspin expression was found in normal breast epithelial cells, but was …

[HTML][HTML] Cytoplasmic maspin expression correlates with poor prognosis of patients with adenocarcinoma of the uterine cervix

K Nosaka, Y Horie, T Shiomi, H Itamochi… - Yonago Acta …, 2015 - ncbi.nlm.nih.gov
Background Maspin is known to be a tumor suppressor protein and its prognostic
significance in patients with several types of cancer has been reported. To date, however, no …