Background: Combretastatin A-4 (CA-4) and its analogs are potent inhibitors of tubulin
polymerization and display strong inhibitory activity on both solid tumor and tumor cell …

A series of benzil derivatives related to combretastatin A-4 (CA-4) have been synthesized by
oxidation of diarylalkynes promoted by PdI2 in DMSO. Using this new protocol, 14 benzils …

A series of novel pyridine-bridged analogues of combretastatin-A4 (CA-4) were designed
and synthesized. As expected, the 4-atom linker configuration retained little cytotoxicities in …

Sixteen 2-cyclohexenone and 6-(ethoxycarbonyl)-2-cyclohexenone analogs of
combretastatin-A4 (CA-4, 1) were synthesized, and their ability to inhibit the growth of two …

Combretastatin A-4 (CA-4) is a natural product, which consists of two phenyl rings, linked by
an ethylene bridge. CA-4, inhibitor of polymerization of tubulin to microtubules, possesses a …

A series of combretastatin A-4 (CA-4) analogues were synthesized, and their cytotoxic
effects against murine Colon 26 adenocarcinoma and inhibitory activity on tubulin …

The combretastatins have received significant attention because of their simple chemical
structures, excellent antitumor efficacy and novel antivascular mechanisms of action. Herein …

Combretastatin A-4 (CA-4) is a potent anti-tumor agent, which strongly inhibits tubulin
polymerization. A common problem is the inactivation of derivatives with cis-configurated …

Studies examining various spacer groups that link the two aromatic rings of combretastatin A-
4 (CA4) have shown that the biological activity of analogs does not require the cis-stilbene …

Novel combretastatin analogues bearing various five-membered heterocycles with
consecutive oxygen and nitrogen atoms, in place of the olefinic bridge of CA4, have been …