Targeted Treatment of HPV16-positive and-negative SCC Cells With Small Molecule Tyrosine Kinase Inhibitors and Everolimus Affects MMP2 and MMP14 Expression

L Huber, R Birk, M Knuettel, N Rotter… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: The rise of targeted therapies in the treatment of head and neck squamous
cell carcinoma (HNSCC) has considerably widened the treatment range. Matrix …

[HTML][HTML] Effect of selective small molecule inhibitors on MMP-9 and VEGFR-1 expression in p16-positive and-negative squamous cell carcinoma

B Kramer, JD Schultz, C Hock, A Sauter… - Oncology …, 2017 - spandidos-publications.com
The identification of molecular targets in the therapy of human papilloma virus (HPV)‑
associated head and neck squamous cell carcinoma (HNSCC) is a primary aim of cancer …

Tyrosine kinase inhibitors and everolimus reduce IGF1R expression in HPV16-positive and-negative squamous cell carcinoma

B Kramer, A Schell, C Aderhold, L Huber… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: The effects of tyrosine kinase inhibitors (TKI) in head and neck squamous
cell cancer (HNSCC) are not fully understood. We investigated the effects of selective TKIs …

Alteration of MMP-2 and-14 expression by imatinib in HPV-positive and-negative squamous cell carcinoma

A Faber, A Sauter, S Hoedt… - Oncology …, 2012 - spandidos-publications.com
Head and neck squamous cell carcinoma (HNSCC) is an aggressive epithelial malignancy.
It is known to be the most common neoplasm appearing in the upper aerodigestive tract. The …

[HTML][HTML] Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro

C Umbreit, C Aderhold, A Faber… - Oncology …, 2014 - spandidos-publications.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer
worldwide. The growth and invasion of HNSCC are strongly influenced by the extracellular …

Association between metalloproteinases 2 and 9 activity and ERK1/2 phosphorylation status in head and neck cancers: an ex vivo study

W Garavello, D Maggioni, G Nicolini… - Oncology …, 2010 - spandidos-publications.com
Advances in clinical treatment of head and neck squamous cell carcinoma (HNSCC) are
hampered by its high infiltrative potential leading to distal metastasis. Since their ability to …

Down-regulation of MMP-2 expression due to inhibition of receptor tyrosine kinases by imatinib and carboplatin in HNSCC

JD Schultz, S Rotunno, P Erben… - Oncology …, 2011 - spandidos-publications.com
Squamous cell carcinoma of the head and neck (HNSCC) is the most common neoplasm
arising in the upper aerodigestive tract. Unfortunately, the survival for this type of cancer has …

Effects of selective MMP‐13 inhibition in squamous cell carcinoma depend on estrogen

A Meides, CM Gutschalk, L Devel… - … journal of cancer, 2014 - Wiley Online Library
Matrix metalloproteinases like MMP‐13 cleave and remodel the extracellular matrix and
thereby play a crucial role in tumor progression in vivo. Using a highly selective inhibitor to …

The role and function of secretory protein MMP3 in cervical cancer

L Shao, X Wang, W Liu, C Zhang, W Ma, X Yu, J Han - 2023 - researchsquare.com
OBJECTIVE Cervical cancer (CCA) is the second commonest malignancy among female all
over the world, and present clinical treatments cannot solve the problems of high metastasis …

MMP9 in Pan-Cancer and Computational Study to Screen MMP9 Inhibitors

B Wu, X Wang, C Chen, Q Yang, P Zhou, S Lu, L Lin… - 2023 - researchsquare.com
Purpose Stromal metalloproteinase 9 (MMP9) is a stromal cell protein associated with
extracellular matrix (ECM) degradation and remodeling, which promotes tumor invasion and …