The human DNA mismatch repair gene hMSH2 is involved in the development of sporadic
and hereditary nonpolyposis colorectal cancer. An increased risk of colorectal cancer has …

Purpose: DNA mismatch repair gene is responsible for hereditary nonpolyposis colorectal
cancer. But it is not well known its role in sporadic colorectal cancer patients. We analysed …

Objective: To investigate the expression of mismatch repair (MMR) proteins (MLH1, MSH2,
MSH6 and PMS2) in colorectal cancers and to explore the relationship between MMR …

Mismatch repair (MMR) genes play an important role in the occurrence and development of
sporadic colorectal cancer; however, the effect of MMR genes on clinicopathological …

Background: Mismatch repair (MMR) deficiency has been related with HNPCCs. So far,
there is limited information on MMR mRNA profiles in sporadic colorectal carcinomas …

Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by
genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the …

Colorectal cancer (CRC) may be classified according to the level of microsatellite instability
exhibited by the tumor. The malignant transformation of normal colonic mucosae to …

At least four genes involved in DNA mismatch repair (MMR), hMSH2, hMLH1, hPMS1 and
hPMS2, have been cloned and characterized. These genes have been demonstrated to be …

To characterize the expression of the mismatch repair gene MSH2 in normal colorectal
crypts in humans and assess parameters of its expression as a potential modifiable …

Microsatellite instability (MSI) is caused by defective mismatch repair (MMR) and is one of
the very few molecular markers with proven clinical importance in colorectal cancer with …