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Apremilast induces apoptosis of human colorectal cancer cells with mutant KRAS

K Nishi, H Luo, S Ishikura, K Doi, Y Iwaihara… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: We previously reported the crucial roles of oncogenic Kirsten rat sarcoma
viral oncogene homologue (KRAS) in inhibiting apoptosis and disrupting cell polarity via the …
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Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture

T Tsunoda, S Ishikura, K Doi, H Matsuzaki… - Anticancer …, 2014 - ar.iiarjournals.org
Background: We have previously reported the crucial roles of oncogenic Kirsten rat sarcoma
viral oncogene homolog (KRAS) in inhibiting apoptosis and disrupting cell polarity via the …
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[HTML] nih.gov

Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis

D Chen, L Wei, J Yu, L Zhang - Clinical cancer research, 2014 - AACR
Purpose: Regorafenib, a multikinase inhibitor targeting the Ras/Raf/MEK/ERK pathway, has
recently been approved for the treatment of metastatic colorectal cancer. However, the …
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[HTML][HTML] DPS-2: a novel dual MEK/ERK and PI3K/AKT pathway inhibitor with powerful ex vivo and in vivo anticancer properties

M Goulielmaki, N Assimomytis, J Rozanc, E Taki… - Translational …, 2019 - Elsevier
Abstract Development of novel bioactive compounds against KRAS and/or BRAF mutant
colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or …
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[HTML][HTML] Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

T Tsunoda, T Ota, T Fujimoto, K Doi, Y Tanaka… - Molecular cancer, 2012 - Springer
Background We previously established a three-dimensional (3-D) colonic crypt model using
HKe3 cells which are human colorectal cancer (CRC) HCT116 cells with a disruption in …
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Epieriocalyxin A induces cell apoptosis through JNK and ERK1/2 signaling pathways in colon cancer cells

Z Wang, Z Xu, Z Niu, B Liang, J Niu - Cell biochemistry and biophysics, 2015 - Springer
Colorectal cancer is one of the most commonly diagnosed cancers in the world. Currently,
drug resistance of cancer cell to chemotherapy is a major cause for cancer recurrence and …
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[HTML][HTML] The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells

N Wei, E Chu, S Wu, P Wipf, JC Schmitz - Oncotarget, 2015 - ncbi.nlm.nih.gov
Metastatic colorectal cancer (mCRC) remains a major public health problem, and diagnosis
of metastatic disease is usually associated with poor prognosis. The multi-kinase inhibitor …
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[HTML][HTML] Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis

Q Han, Y Ma, H Wang, Y Dai, C Chen, Y Liu… - Journal of translational …, 2018 - Springer
Background Necroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we
report that resibufogenin, a member of bufadienolide family, suppresses the growth and …
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Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib

CS Wu, SY Wu, HC Chen, CA Chu, HH Tang… - The Journal of …, 2019 - Elsevier
Curcumin, a major yellow pigment and spice in turmeric and curry, has been demonstrated
to have an anticancer effect in human clinical trials. Mutation of KRAS has been shown in …
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Inhibition of AURKA reduces proliferation and survival of gastrointestinal cancer cells with activated KRAS by preventing activation of RPS6KB1

L Wang-Bishop, Z Chen, A Gomaa, AC Lockhart… - Gastroenterology, 2019 - Elsevier
Background & Aims Activation of KRAS signaling and overexpression of the aurora kinase A
(AURKA) are often detected in luminal gastrointestinal cancers. We investigated regulation …
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