Tropomyosin-related Kinase B is potentially a biomarker of prognosis and therapeutic target for malignant thymic epithelial tumors

K Ozono, H Onishi, N Iwamoto, K Nakamura… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Thymic epithelial tumors (TETs) mainly consist of thymoma and thymic
carcinoma. Complete surgical resection is vital for the successful management of these …

[HTML][HTML] Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma

K Ozono, Y Ohishi, H Onishi, K Nakamura… - Laboratory …, 2017 - nature.com
The tropomyosin-related kinase (Trk) family consists of TrkA, TrkB, and TrkC, which play
essential roles in tumor progression and/or suppression in various cancers. Little is known …

[HTML][HTML] Clinical significance of TrkB expression in nasopharyngeal carcinoma

SS Li, JJ Liu, S Wang, QL Tang… - Oncology …, 2014 - spandidos-publications.com
Recent research has demonstrated that tropomyosin‑related kinase B (TrkB) plays an
important role in neuronal survival, differentiation and migration; yet, its specific role in …

Expression and clinical significance of TrkB in sinonasal squamous cell carcinoma: a pilot study

L Li, L Zhu - International journal of oral and maxillofacial surgery, 2017 - Elsevier
Previous studies have confirmed that tropomyosin-related kinase B (TrkB) plays a critical
role in the occurrence, development, and metastasis of many kinds of malignant tumour …

Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma

Y Goto, Y Kametani, A Kikugawa, B Tsuda… - BioScience …, 2014 - jstage.jst.go.jp
Tropomyosin-related kinase B (TrkB) is a functional signal molecule that correlates with cell
survival and epithelial-mesenchymal transition (EMT), which is essential for the …

Implications of tropomyosin-related kinase B (TrkB) in head and neck cancer

L Zhu, JA Werner, R Mandic - Anticancer research, 2007 - ar.iiarjournals.org
Background: Head and neck squamous cell carcinomas (HNSCC) represent the most
common malignancies of the upper aerodigestive tract. Expression of tropomyosin-related …

TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma

S Odate, K Nakamura, H Onishi, M Kojima, A Uchiyama… - Lung Cancer, 2013 - Elsevier
Tropomyosin-related kinase B (TrkB) plays an important role in tumor progression in various
kinds of cancers; however, little is known about biological significance of TrkB in human lung …

[HTML][HTML] The prognostic value of over-expressed TrkB in solid tumors: a systematic review and meta-analysis

C Zhang, X Li, D Gao, H Ruan, Z Lin, X Li, G Liu, Z Ma… - Oncotarget, 2017 - ncbi.nlm.nih.gov
It is reported recently Tropomyosin-related receptor Kinase B (TrkB) plays key roles in the
anoikis resistance during the processes of tumorigenesis and metastasis. However, its …

[PDF][PDF] Tropomyosin-related kinase B (TrkB) full-length isoform is related to advanced-stage clear cell ovarian cancer (CCOC)

Y Goto, E Wysocka, S Michalak… - Eur. J. Gynaecol …, 2021 - oss.ejgo.net
Objective: Tropomyosin-related kinase B receptor (TrkB) is a receptor tyrosine kinase (RTK)
that regulates the follicular growth and oocyte survival in the ovaries and is overexpressed in …

Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer

A Kamiya, M Inokuchi, S Otsuki, H Sugita… - Clinical and …, 2016 - Springer
Abstract Purpose Tropomyosin-related kinase (Trk) receptors play critical roles in tumor
development and are considered attractive targets for cancer therapy. We investigated …