Most patients with musculoskeletal sarcoma do not recover satisfactory limb function after
limb salvage surgery. To achieve satisfactory improvement of limb function, we developed a …

Limb salvage involving wide resection and reconstruction is now well established for
managing musculoskeletal sarcomas. However, involvement of major nerves and vessels …

Background To maintain excellent limb function after tumor resection in patients with high‐
grade malignant sarcomas, we developed and established a new surgical adjuvant therapy …

We recently established the new limb salvage modality of acridine orange (AO) therapy
(AOT), in an attempt to develop minimally invasive limb salvage surgery with minimal …

Background: Intra-operative photodynamic therapy has been applied with acridine orange
(AO-PDT) to human musculoskeletal sarcomas for the past 4 years, resulting in a low local …

Synovial sarcoma (SS) is one of common malignant softtissue tumors and is encountered
most commonly in children and young adults. It frequently involves or invades major …

Acridine orange (AO) has unique biological actions enabling tumor visualization
(fluorovisualization) and a strong cytocidal effect (photodynamic therapy: AO-PDT) under …

We recently established a unique therapeutic modality for musculoskeletal sarcomas,
combining acridine orange (AO) with photodynamic surgery (PDS), photodynamic therapy …

Rhabdomyosarcoma is a common malignant soft tissue that frequently involves bone and
major neurovascular structures and resection of deep-seated rhabdomyosarcoma can …

During the past 20 years, we have found that acridine orange (AO) selectively accumulates
in musculoskeletal sarcomas in vivo or exerts selective cytocidal effects against sarcoma …