Chemoradiotherapy in cancer treatment: Rationale and clinical applications
Chemoradiotherapy (CRT) refers to the combined administration of both chemotherapy and
radiotherapy as an anticancer treatment. Over the years, CRT has become an established …
radiotherapy as an anticancer treatment. Over the years, CRT has become an established …
[HTML][HTML] Radiotherapy–immunotherapy combination: how will we bridge the gap between pre-clinical promise and effective clinical delivery?
E Romano, J Honeychurch, TM Illidge - Cancers, 2021 - mdpi.com
Simple Summary Radiotherapy is an important component of cancer treatment, given to
around half of all cancer patients. Radiotherapy is known to be very effective at directly …
around half of all cancer patients. Radiotherapy is known to be very effective at directly …
[HTML][HTML] Developments in combining targeted radionuclide therapies and immunotherapies for cancer treatment
CP Kerr, JJ Grudzinski, TP Nguyen, R Hernandez… - Pharmaceutics, 2022 - mdpi.com
Targeted radionuclide therapy (TRT) and immunotherapy are rapidly growing classes of
cancer treatments. Basic, translational, and clinical research are now investigating …
cancer treatments. Basic, translational, and clinical research are now investigating …
Emerging evidence for adapting radiotherapy to immunotherapy
L Galluzzi, MJ Aryankalayil, CN Coleman… - Nature reviews Clinical …, 2023 - nature.com
Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …
infrequently associated with durable objective responses when used as a standalone …
[HTML][HTML] The confluence of radiotherapy and immunotherapy
B Burnette, YX Fu, RR Weichselbaum - Frontiers in oncology, 2012 - frontiersin.org
Radiotherapy (RT) has been considered a local modality and outcomes have emphasized
local and regional control of tumors. Recent data suggests that RT may activate the immune …
local and regional control of tumors. Recent data suggests that RT may activate the immune …
Radiotherapy–immunotherapy combinations–perspectives and challenges
Ionizing radiation has historically been used to treat cancer by killing tumour cells, in
particular by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic …
particular by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic …
[HTML][HTML] Synergizing radiotherapy and immunotherapy: Current challenges and strategies for optimization
G Rajeev-Kumar, SP Pitroda - Neoplasia, 2023 - Elsevier
Numerous clinical studies are investigating the integration of radiotherapy and immune
checkpoint inhibitors (ICI) in the management of advanced or metastatic solid cancers based …
checkpoint inhibitors (ICI) in the management of advanced or metastatic solid cancers based …
The reciprocity between radiotherapy and cancer immunotherapy
The clinical success of immune checkpoint inhibitors in treating metastatic and refractory
cancers has generated significant interest in investigating their role in treating locally …
cancers has generated significant interest in investigating their role in treating locally …
[HTML][HTML] Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations
M Colton, EJ Cheadle, J Honeychurch, TM Illidge - Radiation Oncology, 2020 - Springer
Radiotherapy (RT) is a highly effective anti-cancer therapy delivered to around 50–60% of
patients. It is part of therapy for around 40% of cancer patients who are cured of their …
patients. It is part of therapy for around 40% of cancer patients who are cured of their …
The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications
M Spiotto, YX Fu, RR Weichselbaum - Science immunology, 2016 - science.org
By inducing DNA damage, radiotherapy both reduces tumor burden and enhances
antitumor immunity. Here, we review the mechanisms by which radiation induces antitumor …
antitumor immunity. Here, we review the mechanisms by which radiation induces antitumor …