Tumor-specific cytotoxicity and type of cell death induced by benzaldehyde

K Ariyoshi-Kishino, KEN Hashimoto, O Amano… - Anticancer …, 2010 - ar.iiarjournals.org
We have previously reported that sodium 5, 6-benzylidene-L-ascorbate (SBA) induced
dramatic antitumor activity in inoperable cancer patients, but induced only marginal tumor …

Tumor-specific cytotoxicity and type of cell death induced by sodium 5, 6-benzylidene-l-ascorbate

K Kishino, K Hashimoto, O Amano, M Kochi… - Anticancer …, 2008 - ar.iiarjournals.org
The cytotoxic activity of sodium 5, 6-benzylidene-L-ascorbate (SBA) against eight human
cancer cell lines and three human normal cells was investigated. SBA showed slightly …

Mitochondrial control of cell death induction by sodium 5, 6-benzylidene-L-ascorbate.

H Fujii, O Amano, M Kochi, H Sakagami - Anticancer research, 2003 - europepmc.org
Previous studies have demonstrated the dramatic antitumor activity of sodium 5, 6-
benzylidene-L-ascorbate (SBA). However, the molecular mechanism of this antitumor action …

Induction of non-apoptotic cell death by sodium 5, 6-benzylidene-L-ascorbate in a human salivary gland tumor cell line.

H Sakagami, K Kusama, M Toguchi, M Kochi - Anticancer research, 1999 - europepmc.org
We investigated whether sodium 5, 6-benzylidene-L-ascorbate (SBA) induces apoptotic cell
death in a human salivary gland tumor cell line HSG, using two different cytochemical …

Benzylideneascorbate induces apoptosis in L929 tumor cells

S Tanuma, D Shiokawa, Y Tanimoto, M Ikekita… - Biochemical and …, 1993 - Elsevier
Abstract Sodium 5, 6-benzylideneascorbate (SBA), which is known to be an antitumor
substance, was found to induce apoptotic cell death of L929 tumor cells directly in a …

Preclinical re-evaluation of benzaldehyde as a chemotherapeutic agent.

R Taetle, SB Howell - Cancer treatment reports, 1983 - europepmc.org
Benzaldehyde (BA), an agent extracted from figs, is reported to have antitumor activity in
vitro against a variety of experimental tumors and in vivo against refractory human …

Sodium 5,6‐benzylidene‐L‐ascorbate induces oxidative stress, autophagy, and growth arrest in human colon cancer HT‐29 cells

FWK Cheung, CT Che, H Sakagami… - Journal of cellular …, 2010 - Wiley Online Library
Our previous studies have demonstrated the oxidative stress properties of sodium ascorbate
(SAA) and its benzaldehyde derivative (SBA) on cancer cell lines, but the molecular …

Effect of sodium benzylideneascorbate on chemically-induced tumors in rats.

H Sakagami, M Takeda, A Utsumi, S Fujinaga… - Anticancer …, 1993 - europepmc.org
Intravenous administration of sodium benzylideneascorbate (SBA) dose-dependently
induced degeneration (vacuolar and eosinophilic degeneration and cell shrinkage and …

[HTML][HTML] Changes in metabolic profiles of human oral cells by benzylidene ascorbates and eugenol

H Sakagami, M Sugimoto, Y Kanda, Y Murakami… - Medicines, 2018 - mdpi.com
Background: Sodium-5, 6-benzylidene-L-ascorbate (SBA), and its component units,
benzaldehyde (BA) and sodium ascorbate (SA), are known to exert antitumor activity, while …

Induction of tumor degeneration by sodium benzylideneascorbate.

H Sakagami, K Asano, K Fukuchi, K Gomi… - Anticancer …, 1991 - europepmc.org
Intravenous administration of sodium benzylideneascorbate (SBA) rapidly necrotized
inoperable human lung cancer, and induced degeneration of 3'-methyl-4 …