Quantitative structure–cytotoxicity relationship of pyrano [4, 3-b] chromones

J Nagai, H Shi, Y Kubota, K Bandow… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: 4H-1-Benzopyran-4-one (chromone) provides a backbone structure for the
chemical synthesis of potent anticancer drugs. Since studies of the biological activity of …

Quantitative structure–cytotoxicity relationship of 3-(N-cyclicamino) chromone derivatives

H Shi, J Nagai, T Sakatsume, K Bandow… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: 4H-1-Benzopyran-4-ones (chromones) provide a backbone structure for
the chemical synthesis of potent anticancer drugs. In contrast to 2-(N-cyclicamino) …

Quantitative structure–cytotoxicity relationship of 2-(N-cyclicamino) chromone derivatives

H Shi, J Nagai, T Sakatsume, K Bandow… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: 4H-1-Benzopyran-4-ones (chromones) have provided backbone structure
for the chemical synthesis of potent anticancer drugs. In this study, the cytotoxicity of fifteen 2 …

Quantitative Structure–Cytotoxicity Relationship of Furo [2, 3-b] chromones

Y Uesawa, H Sakagami, H Shi, M Hirose… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: The furo [2, 3-b] chromone derivatives are natural products that have been
used as folklore medicines for various diseases. Here, the cytotoxicity of 12 synthesized furo …

Quantitative structure–cytotoxicity relationship of 2-arylazolylchromones and 2-triazolylchromones

J Nagai, H Shi, N Sezaki, N Yoshida… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: 4H-1-Benzopyran-4-one (chromone), present in various flavonoids as a
backbone structure, has been used for the synthesis of anticancer drugs. The study aimed at …

In vitro anticancer activity of pyrano[3, 2-c]chromene derivatives with both cell cycle arrest and apoptosis induction

AM El-Agrody, AM Fouda, MA Assiri, A Mora… - Medicinal Chemistry …, 2020 - Springer
Abstract A series of 2-amino-4-aryl-5-oxo-4, 5-dihydropyrano [3, 2-c] chromene-3-
carbonitrile (4a–m) were synthesized via a one-pot three component condensation reaction …

[HTML][HTML] Development of newly synthesized chromone derivatives with high tumor specificity against human oral squamous cell carcinoma

Y Sugita, K Takao, Y Uesawa, J Nagai, Y Iijima… - Medicines, 2020 - mdpi.com
Since many anticancer drugs show severe adverse effects such as mucositis, peripheral
neurotoxicity, and extravasation, it was crucial to explore new compounds with much …

Quantitative structure–cytotoxicity relationship of 3-styryl-2H-chromenes

Y Uesawa, H Sakagami, M Ishihara… - Anticancer …, 2015 - ar.iiarjournals.org
Background: Sixteen 3-styryl-2H-chromenes were subjected to quantitative structure–activity
relationship analysis based on their cytotoxicity, tumor selectivity and anti-HIV activity, in …

QSAR Study of 4‐Aryl‐4H‐Chromenes as a New Series of Apoptosis Inducers Using Different Chemometric Tools

M Khoshneviszadeh, N Edraki, R Miri… - Chemical biology & …, 2012 - Wiley Online Library
The apoptosis‐inducing activity data of a series of 4‐aryl‐4H‐chromenes based on three
cell lines (human breast cancer cell line T47D, human non‐smal cell lung cancer cell line …

Synthesis and characterization of novel 4-aryl-4H-chromene derivatives using borax and evaluation of their anticancer effects

H Adibi, L Hosseinzadeh… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Background/Introduction: 4-aryl-4H-chromenes have attracted attention as potential
anticancer agents. Objective: In an effort to discover effective compounds, we designed a …