Pan-Aurora Kinase Inhibitor Danusertib Induces Apoptosis of Epstein–Barr Virus-transformed B-Cells Through Caspase and Endoplasmic Reticulum Stress Signaling

JS Kim, DY Hur - Anticancer Research, 2022 - ar.iiarjournals.org
Abstract Background/Aim: Evidence for the relevance of Epstein–Barr virus (EBV) in various
types of cancer has expanded; however, the definitive mechanism of EBV-induced …

EBNA3C-mediated regulation of aurora kinase B contributes to Epstein-Barr virus-induced B-cell proliferation through modulation of the activities of the retinoblastoma …

HC Jha, J Lu, A Saha, Q Cai, S Banerjee… - Journal of …, 2013 - Am Soc Microbiol
Epstein-Barr virus (EBV) is an oncogenic gammaherpesvirus that is implicated in several
human malignancies, including Burkitt's lymphoma (BL), posttransplant lymphoproliferative …

Exploring the Plausible Role of Aurora Kinase A in Epstein-Barr Virus Mediated Gastric Cancer Progression

N Varshney, S Murmu, B Baral, D Kashyap… - Available at SSRN … - papers.ssrn.com
Aims: In the current study, we explored the importance of Aurora kinase A (AURKA) in
Epstein Barr Virus-induced gastric cancer progression and the possible interaction involved …

Unraveling the Aurora kinase A and Epstein-Barr nuclear antigen 1 axis in Epstein Barr virus associated gastric cancer

N Varshney, S Murmu, B Baral, D Kashyap, S Singh… - Virology, 2023 - Elsevier
Aurora kinase A (AURKA) is one of the crucial cell cycle regulators associated with gastric
cancer. Here, we explored Epstein Barr Virus-induced gastric cancer progression through …

Aurora B kinase: a potential drug target for cancer therapy

A Ahmed, A Shamsi, T Mohammad, GM Hasan… - Journal of cancer …, 2021 - Springer
Background Ensuring genetic integrity is essential during the cell cycle to avoid aneuploidy,
one of the underlying causes of malignancies. Aurora kinases are serine/threonine kinase …

Reactive oxygen species generation and increase in mitochondrial copy number: new insight into the potential mechanism of cytotoxicity induced by aurora kinase …

A Zekri, Y Mesbahi, S Ghanizadeh-Vesali… - Anti-cancer …, 2017 - journals.lww.com
Aurora-B kinase overexpression plays important roles in the malignant progression of
prostate cancer (PCa). AZD1152-HQPA, as an inhibitor of Aurora-B, has recently emerged …

[HTML][HTML] The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect

K Jiang, L Bai, C Wang, X Xiao, Z Cheng, H Peng… - PeerJ, 2023 - peerj.com
Objective To investigate the effect of the kinase inhibitor AT9283 on Burkitt lymphoma (BL)
cells and elucidate the underlying mechanisms. Methods The effect of AT9283 on the …

Alisertib (MLN8237), a selective Aurora-A kinase inhibitor, induces apoptosis in human tongue squamous cell carcinoma cell both in vitro and in vivo

L Qi, Y Zhang - Tumor Biology, 2015 - Springer
Aurora-A kinases are overexpressed in many cancer tissues and cells. Alisertib is an
investigational, orally administered, selective, small-molecule Aurora-A kinase inhibitor with …

[HTML][HTML] Combined inhibition of aurora kinases and Bcl-xL induces apoptosis through select BH3-only proteins

J Li, CH Chen, KL O'Neill, VJ Fousek-Schuller… - Journal of Biological …, 2023 - ASBMB
Aurora kinases (AURKs) are mitotic kinases important for regulating cell cycle progression.
Small-molecule inhibitors of AURK have shown promising antitumor effects in multiple …

Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways

M Li, A Jung, U Ganswindt, P Marini, A Friedl… - Biochemical …, 2010 - Elsevier
ZM447439 (ZM) is a potent and selective inhibitor of aurora-A and-B kinase with putative
anti-tumoral activity. Inhibitors of aurora kinases were shown to induce apoptosis in vitro and …