Towards a personalized approach in pancreatic cancer diagnostics through plasma amino acid analysis

J Tumas, I Baskirova, T Petrenas… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Body fluid biomarkers may provide means for early pancreatic cancer
diagnosis, patient stratification, application of personalized approaches and, finally …

Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer

S Urayama, W Zou, K Brooks… - … in Mass Spectrometry …, 2010 - Wiley Online Library
Poor outcome of pancreatic cancer necessitates development of an early diagnostic method
to reduce mortality. No reliable early diagnostic test for pancreatic cancer detection has …

[HTML][HTML] Evaluating metabolite-based biomarkers for early diagnosis of pancreatic cancer: a systematic review

G Perazzoli, OM García-Valdeavero, M Peña, J Prados… - Metabolites, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year
survival rates around 10%. The only curative option remains complete surgical resection, but …

Search for early pancreatic cancer blood biomarkers in five European prospective population biobanks using metabolomics

J Fest, LS Vijfhuizen, JJ Goeman, O Veth… - …, 2019 - academic.oup.com
Most patients with pancreatic cancer present with advanced disease and die within the first
year after diagnosis. Predictive biomarkers that signal the presence of pancreatic cancer in …

Feasibility of identifying pancreatic cancer based on serum metabolomics

OF Bathe, R Shaykhutdinov, K Kopciuk… - … , biomarkers & prevention, 2011 - AACR
Background: We postulated that the abundance of various metabolites in blood would
facilitate the diagnosis of pancreatic and biliary lesions, which could potentially prevent …

[HTML][HTML] Metabolomic profile in pancreatic cancer patients: a consensus-based approach to identify highly discriminating metabolites

IM Di Gangi, T Mazza, A Fontana, M Copetti, C Fusilli… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Purpose pancreatic adenocarcinoma is the fourth leading cause of cancer related deaths
due to its aggressive behavior and poor clinical outcome. There is a considerable variability …

A systematic review on metabolomics-based diagnostic biomarker discovery and validation in pancreatic cancer

NP Long, SJ Yoon, NH Anh, TD Nghi, DK Lim, YJ Hong… - Metabolomics, 2018 - Springer
Introduction Metabolomics is an emerging approach for early detection of cancer. Along with
the development of metabolomics, high-throughput technologies and statistical learning, the …

[HTML][HTML] Tissue amino acid profiles are characteristic of tumor type, malignant phenotype, and tumor progression in pancreatic tumors

N Hiraoka, S Toue, C Okamoto, S Kikuchi, Y Ino… - Scientific Reports, 2019 - nature.com
Tissue amino acid profiles depend on the cell types and extracellular components that
constitute the tissue, and their functions and activities. We aimed to characterize the tissue …

Plasma metabolite biomarkers for the detection of pancreatic cancer

G Xie, L Lu, Y Qiu, Q Ni, W Zhang, YT Gao… - Journal of proteome …, 2015 - ACS Publications
Patients with pancreatic cancer (PC) are usually diagnosed at late stages, when the disease
is nearly incurable. Sensitive and specific markers are critical for supporting diagnostic and …

[HTML][HTML] Profiling the metabolic disorder and detection of colorectal cancer based on targeted amino acids metabolomics

Y Yang, Z Wang, X Li, J Lv, R Zhong, S Gao… - Journal of Translational …, 2023 - Springer
Background The morbidity of cancer keeps growing worldwide, and among that, the
colorectal cancer (CRC) has jumped to third. Existing early screening tests for CRC are …