Benefit of Gene Expression Profiling in Gastrointestinal Neuroendocrine Tumors of Unknown Primary Origin

JJ Saller, M Haider, S Al-Diffalha… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Cancer of unknown primary (CUP), representing 3-5% of all newly
diagnosed cancers in the United States, is a presumptive, non-definitive diagnosis rendered …

[HTML][HTML] Transcriptome analysis of primary sporadic neuroendocrine tumours of the intestine identified three different molecular subgroups

P Mattiolo, A Gkountakos, G Centonze… - … -Research and Practice, 2023 - Elsevier
Background Intestinal neuroendocrine tumours (I-NETs) represent a non-negligible entity
among intestinal neoplasms, with metastatic spreading usually present at the time of …

[HTML][HTML] Multidisciplinary approach to the diagnosis of occult primary neuroendocrine neoplasm: a clinical challenge

RE Rossi, F Corti, S Pusceddu, M Milione… - Journal of Clinical …, 2023 - mdpi.com
Approximately 11% to 14% of subjects with neuroendocrine neoplasms (NENs) have
metastatic lesions with unknown primary origin (UPO), with the majority of UPO-NENs found …

An update on the development of concepts, diagnostic criteria, and challenging issues for neuroendocrine neoplasms across different digestive organs

A Couvelard, J Cros - Virchows Archiv, 2022 - Springer
Digestive neuroendocrine neoplasms (NENs) are a group of heterogeneous neoplasms
found throughout the digestive tract, with different behaviour and genetic background. In the …

Current concepts in the diagnosis and management of neuroendocrine neoplasms of unknown primary origin.

KI Alexandraki, M Tsoli, G Kyriakopoulos… - Minerva …, 2019 - europepmc.org
Neuroendocrine neoplasms (NENs) of unknown primary origin (UPO-NENs) are advanced
neoplasms constituting 11-22% of all NENs that by definition their primary tissue of origin …

[HTML][HTML] Relation between WHO classification and location-and functionality-based classifications of neuroendocrine neoplasms of the digestive tract

NC Helderman, M Suerink, G Kilinç… - …, 2024 - karger.com
Practice of neuroendocrine neoplasms (NENs) of the digestive tract, which comprise of a
highly diverse group of tumors with a rising incidence, faces multiple biological, diagnostic …

[HTML][HTML] Perspectives on the diagnostic, predictive and prognostic markers of neuroendocrine neoplasms

OA Ciobanu, S Martin, S Fica - Experimental and …, 2021 - spandidos-publications.com
Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare tumors with different
types of physiology and prognosis. Therefore, prognostic information, including …

Genomics of high-grade neuroendocrine neoplasms: well-differentiated neuroendocrine tumor with high-grade features (G3 NET) and neuroendocrine carcinomas …

S Uccella, S La Rosa, J Metovic, D Marchiori… - Endocrine …, 2021 - Springer
High-grade neuroendocrine neoplasms (HG-NENs) are clinically aggressive diseases, the
classification of which has recently been redefined. They now include both poorly …

A real-world, population-based study for the incidence and outcomes of neuroendocrine neoplasms of unknown primary

O Abdel-Rahman - Neuroendocrinology, 2021 - karger.com
Objective: The aim of the study was to provide a real-world, population-based assessment of
the incidence and outcomes of neuroendocrine neoplasms (NENs) of unknown primary …

Clinical implications of pathogenic germline variants in small intestine neuroendocrine tumors (SI-NETs)

K Perez, MH Kulke, A Chittenden, C Ukaegbu… - JCO Precision …, 2021 - ascopubs.org
PURPOSE An inherited basis for presumed sporadic neuroendocrine tumor (NET) has been
suggested by evidence of familial clustering of NET and a higher incidence of second …