The combination of flavokawain B and daunorubicin induces apoptosis in human myeloid leukemic cells by modifying NF-κB
JJ Lee, KN Koh, CJ Park, S Jang, HJ Im… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Flavokawain B (FKB), is a natural chalcone isolated from kava root that
induces apoptosis in cancer cells. Herein we investigated the effects of combination of FKB …
induces apoptosis in cancer cells. Herein we investigated the effects of combination of FKB …
[HTML][HTML] Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
Background Osteosarcoma (OS) is the most common primary bone malignancy with a high
propensity for local invasion and distant metastasis. Limited by the severe toxicity of …
propensity for local invasion and distant metastasis. Limited by the severe toxicity of …
In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice
N Abu, NE Mohamed, SK Yeap, KL Lim… - Drug design …, 2015 - Taylor & Francis
Flavokawain B (FKB) is a naturally occurring chalcone that can be isolated through the root
extracts of the kava-kava plant (Piper methysticum). It can also be synthesized chemically to …
extracts of the kava-kava plant (Piper methysticum). It can also be synthesized chemically to …
Cyclization of flavokawain B reduces its activity against human colon cancer cells
A Palko-Łabuz, E Kostrzewa-Susłow… - Human & …, 2020 - journals.sagepub.com
Chalcones are naturally occurring compounds exhibiting biological activity through multiple
mechanisms. Flavokawain B is one of chalcones found in kava plant. In our studies, we …
mechanisms. Flavokawain B is one of chalcones found in kava plant. In our studies, we …
[HTML][HTML] Flavokawain C inhibits cell cycle and promotes apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways …
CW Phang, SA Karsani, G Sethi, SN Abd Malek - PLoS One, 2016 - journals.plos.org
Flavokawain C (FKC) is a naturally occurring chalcone which can be found in Kava (Piper
methysticum Forst) root. The present study evaluated the effect of FKC on the growth of …
methysticum Forst) root. The present study evaluated the effect of FKC on the growth of …
[HTML][HTML] Flavokawain A Induces Apoptosis in MCF-7 and MDA-MB231 and Inhibits the Metastatic Process In Vitro
Introduction The kava-kava plant (Piper methsyticum) is traditionally known as the pacific
elixir by the pacific islanders for its role in a wide range of biological activities. The extract of …
elixir by the pacific islanders for its role in a wide range of biological activities. The extract of …
Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms
YL Tang, LB Huang, Y Tian, LN Wang… - Leukemia & …, 2015 - Taylor & Francis
The development of novel chemotherapeutic drugs is needed for the treatment of patients
with acute lymphoblastic leukemia (ALL). In this study, the anti-leukemic effect and the …
with acute lymphoblastic leukemia (ALL). In this study, the anti-leukemic effect and the …
The kava chalcone flavokawain B exerts inhibitory activity and synergizes with BCL-2 inhibition in malignant B-cell lymphoma
M Zhao, X Jiang, J Fang, Y Lin, Y Li, R Pei, P Ye, Y Lu… - Phytomedicine, 2023 - Elsevier
Background B-cell lymphoma, which originates from B cells at diverse differentiation stages,
is the most common non-Hodgkin lymphoma with tremendous treatment challenges and …
is the most common non-Hodgkin lymphoma with tremendous treatment challenges and …
[HTML][HTML] Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the …
Background The kava-kava plant (Piper methysticum) is traditionally consumed by the
pacific islanders and has been linked to be involved in several biological activities …
pacific islanders and has been linked to be involved in several biological activities …
[HTML][HTML] Induction of apoptosis and cell cycle arrest by flavokawain C on HT-29 human colon adenocarcinoma via enhancement of reactive oxygen species generation …
CW Phang, SA Karsani… - Pharmacognosy …, 2017 - ncbi.nlm.nih.gov
Chalcones have been shown to exhibit anti-cancer properties by targeting multiple
molecular pathways. It was, therefore, of interest to investigate flavokawain C (FKC), a …
molecular pathways. It was, therefore, of interest to investigate flavokawain C (FKC), a …