Background/Aim: Flavokawain B (FKB), is a natural chalcone isolated from kava root that
induces apoptosis in cancer cells. Herein we investigated the effects of combination of FKB …

Background Osteosarcoma (OS) is the most common primary bone malignancy with a high
propensity for local invasion and distant metastasis. Limited by the severe toxicity of …

Flavokawain B (FKB) is a naturally occurring chalcone that can be isolated through the root
extracts of the kava-kava plant (Piper methysticum). It can also be synthesized chemically to …

Chalcones are naturally occurring compounds exhibiting biological activity through multiple
mechanisms. Flavokawain B is one of chalcones found in kava plant. In our studies, we …

Flavokawain C (FKC) is a naturally occurring chalcone which can be found in Kava (Piper
methysticum Forst) root. The present study evaluated the effect of FKC on the growth of …

Introduction The kava-kava plant (Piper methsyticum) is traditionally known as the pacific
elixir by the pacific islanders for its role in a wide range of biological activities. The extract of …

The development of novel chemotherapeutic drugs is needed for the treatment of patients
with acute lymphoblastic leukemia (ALL). In this study, the anti-leukemic effect and the …

Background B-cell lymphoma, which originates from B cells at diverse differentiation stages,
is the most common non-Hodgkin lymphoma with tremendous treatment challenges and …

Background The kava-kava plant (Piper methysticum) is traditionally consumed by the
pacific islanders and has been linked to be involved in several biological activities …

Chalcones have been shown to exhibit anti-cancer properties by targeting multiple
molecular pathways. It was, therefore, of interest to investigate flavokawain C (FKC), a …