Synthetic inhibitors of galectin-1 and-3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
IDA Iurisci, A Cumashi, AA Sherman… - Anticancer …, 2009 - ar.iiarjournals.org
Background: Galectins have emerged as critical regulators of tumor progression and
metastasis, by modulating different biological events including homotypic cell aggregation …
metastasis, by modulating different biological events including homotypic cell aggregation …
Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial …
GA Rabinovich, A Cumashi, GA Bianco… - …, 2006 - academic.oup.com
Galectins, a family of structurally related carbohydrate-binding proteins, contribute to
different events associated with cancer biology, including apoptosis, homotypic cell …
different events associated with cancer biology, including apoptosis, homotypic cell …
Unraveling galectin-1 as a novel therapeutic target for cancer
L Astorgues-Xerri, ME Riveiro… - Cancer treatment …, 2014 - Elsevier
Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-
galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues …
galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues …
Novel selective galectin-3 antagonists are cytotoxic to acute lymphoblastic leukemia
K Bum-Erdene, PM Collins, MW Hugo… - Journal of Medicinal …, 2022 - ACS Publications
Galectin-3 is a β-galactoside-specific, carbohydrate-recognizing protein (lectin) that is
strongly implicated in cancer development, metastasis, and drug resistance. Galectin-3 …
strongly implicated in cancer development, metastasis, and drug resistance. Galectin-3 …
Galectin-3 as a potential target to prevent cancer metastasis
H Ahmed, DMM AlSadek - Clinical Medicine Insights …, 2015 - journals.sagepub.com
Interactions between two cells or between cell and extracellular matrix mediated by protein–
carbohydrate interactions play pivotal roles in modulating various biological processes such …
carbohydrate interactions play pivotal roles in modulating various biological processes such …
Galectin‐3 overexpression protects from apoptosis by improving cell adhesion properties
P Matarrese, O Fusco, N Tinari, C Natoli… - … journal of cancer, 2000 - Wiley Online Library
Galectin‐3 is a carbohydrate‐binding protein endowed with affinity for β‐galactosides. It
plays a role in cell–cell and cell–matrix interactions. Furthermore, it has been hypothesized …
plays a role in cell–cell and cell–matrix interactions. Furthermore, it has been hypothesized …
Inhibition of galectins with small molecules
CT Öberg, H Leffler, UJ Nilsson - Chimia, 2011 - chimia.ch
Evidence that the galectin family of proteins plays crucial roles in cancer, inflammation, and
immunity has accumulated over the last decade. The galectins have consequently emerged …
immunity has accumulated over the last decade. The galectins have consequently emerged …
[HTML][HTML] Galectin-1 as a potential cancer target
GA Rabinovich - British Journal of Cancer, 2005 - nature.com
Galectins are a family of structurally related carbohydrate-binding proteins, which are
defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and …
defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and …
Cell surface N-glycosylation and sialylation regulate galectin-3-induced apoptosis in human diffuse large B cell lymphoma
O Suzuki, M Abe - Oncology reports, 2008 - spandidos-publications.com
Galectin-3 is a soluble endogenous lectin in vertebrates and is implicated in a variety of
biological functions, including tumor cell adhesion, proliferation, differentiation, apoptosis …
biological functions, including tumor cell adhesion, proliferation, differentiation, apoptosis …
Galectin-1 inhibitors and their potential therapeutic applications: a patent review
H Blanchard, K Bum-Erdene, MH Bohari… - Expert Opinion on …, 2016 - Taylor & Francis
Introduction: Galectins have affinity for β-galactosides. Human galectin-1 is ubiquitously
expressed in the body and its expression level can be a marker in disease. Targeted …
expressed in the body and its expression level can be a marker in disease. Targeted …