Casein kinase 2 inhibitor, CX-4945, as a potential targeted anticancer agent in gastric cancer
HM Kim, I Jeong, HJ Kim, SK Kang, WS Kwon… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Casein kinase 2 (CK2) is involved in multiple cellular processes.
Furthermore, its overexpression in several human cancers has been associated with tumor …
Furthermore, its overexpression in several human cancers has been associated with tumor …
Druggability of the CK2 inhibitor CX-4945 as an anticancer drug and beyond
J Kim, SH Kim - Archives of pharmacal research, 2012 - Springer
Abstract Casein kinase 2 (CK2) is involved in multiple cellular processes such as
proliferation, apoptosis, and cell cycle. In particular, its over-expression in human cancers is …
proliferation, apoptosis, and cell cycle. In particular, its over-expression in human cancers is …
[HTML][HTML] Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer
M Jung, KH Park, HM Kim, TS Kim, X Zhang, SM Park… - Gastric Cancer, 2019 - Springer
Purpose Casein kinase (CK) 2 activation has been implicated in the proliferation of various
tumor types and resistance to chemotherapy. We investigated the mechanistic basis for the …
tumor types and resistance to chemotherapy. We investigated the mechanistic basis for the …
IC261 suppresses progression of hepatocellular carcinoma in a casein kinase 1 δ/ε independent manner
F Yuan, D Li, M Guo, T Fang, J Sun, F Qi, Q Rao… - Biochemical and …, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide that responds
poorly to existing therapies. The Casein kinase 1 (CK1) isoforms CK1δ and CK1ε are …
poorly to existing therapies. The Casein kinase 1 (CK1) isoforms CK1δ and CK1ε are …
[HTML][HTML] The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies
HJ Chon, KJ Bae, Y Lee, J Kim - Frontiers in pharmacology, 2015 - frontiersin.org
The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in
treatment of various human cancers. CK2 overexpression has been demonstrated in …
treatment of various human cancers. CK2 overexpression has been demonstrated in …
[HTML][HTML] Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via …
S Wang, AK Yadav, JY Han, KS Ahn… - International Journal of …, 2022 - mdpi.com
Overexpression of casein kinase 2 (CK2) has an oncogenic and pro-survival role in many
cancers. CX-4945 (Silmitasertib) is a CK2 inhibitor with anti-cancerous and anti-angiogenic …
cancers. CX-4945 (Silmitasertib) is a CK2 inhibitor with anti-cancerous and anti-angiogenic …
[HTML][HTML] Casein Kinase 2: a novel player in glioblastoma therapy and cancer stem cells
Abstract Casein kinase 2 (CK2) is an oncogenic protein kinase which contributes to tumor
development, proliferation, and suppression of apoptosis in multiple cancer types. The …
development, proliferation, and suppression of apoptosis in multiple cancer types. The …
[HTML][HTML] Inhibition of casein kinase 2 prevents growth of human osteosarcoma
K Takahashi, T Setoguchi, A Tsuru… - Oncology …, 2017 - spandidos-publications.com
High-dose chemotherapy and surgical treatment have improved the prognosis of
osteosarcoma. However, more than 20% of patients with osteosarcoma still have a poor …
osteosarcoma. However, more than 20% of patients with osteosarcoma still have a poor …
[HTML][HTML] Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2
S Liu, D Hsieh, YL Yang, Z Xu, C Peto… - BMC Pharmacology and …, 2013 - Springer
Abstract Background Casein kinase 2 (CK2) is involved in various cellular events such as
proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple …
proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple …
Pharmacokinetic characterization of CK2 inhibitor CX-4945
YH Son, JS Song, SH Kim, J Kim - Archives of pharmacal research, 2013 - Springer
Over-expression of protein kinase CK2 is highly linked to the survival of cancer cells and the
poor prognosis of patients with cancers. CX-4945, a potent and selective orally bioavailable …
poor prognosis of patients with cancers. CX-4945, a potent and selective orally bioavailable …