Tumor-infiltrating ICOS+ Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and 'Hot'Tumor
H Kajikawa, M Hirata, M Haruna, A Ueyama… - Anticancer …, 2022 - ar.iiarjournals.org
Background: Tumor immunity in the tumor microenvironment is activated in patients with
feasible clinical responses to immune checkpoint inhibitors. The immunological profile of …
feasible clinical responses to immune checkpoint inhibitors. The immunological profile of …
Clinical significance of tumor‐associated immune cells in patients with oral squamous cell carcinoma
M Kikuchi, D Yamashita, S Hara, S Takebayashi… - Head & …, 2021 - Wiley Online Library
Background The expression of PD‐L1 in tumor cells and infiltration of tumor‐associated
immune cells (TAICs) might reflect the tumor biology of head and neck cancer. We aimed to …
immune cells (TAICs) might reflect the tumor biology of head and neck cancer. We aimed to …
The Infiltration of ICOS+ Cells in Nasopharyngeal Carcinoma is Beneficial for Improved Prognosis
G Zhang, Y Xu, H Zhou - Pathology & Oncology Research, 2020 - Springer
Nasopharyngeal carcinoma (NPC) is a highly malignant tumor, associated with poor patient
prognoses, and high rates of morbidity and mortality. Currently, immune checkpoint therapy …
prognoses, and high rates of morbidity and mortality. Currently, immune checkpoint therapy …
[HTML][HTML] Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma
A Lechner, H Schlößer, SI Rothschild, M Thelen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The composition of tumor-infiltrating lymphocytes (TIL) reflects biology and immunogenicity
of cancer. Here, we characterize T-cell subsets and expression of immune checkpoint …
of cancer. Here, we characterize T-cell subsets and expression of immune checkpoint …
ICOS/ICOSLG and PD-1 Co-expression is associated with the progression of colorectal precancerous-carcinoma immune microenvironment
Y Zhang, XL Wang, JJ Liu, ZY Qian… - Journal of …, 2023 - Taylor & Francis
Purpose This study aimed to investigate the expression of inducible T-cell co-stimulator
(ICOS) and its ligand (ICOSLG), along with their association with clinicopathological features …
(ICOS) and its ligand (ICOSLG), along with their association with clinicopathological features …
The high expression of immune checkpoint co-stimulators predicts a favorable prognosis in head and neck carcinomas
Objectives: T cells require second immune checkpoint molecules for activation and immune
memory after antigen presentation. In our previous study, we found ICOS a favorable …
memory after antigen presentation. In our previous study, we found ICOS a favorable …
The clinical impact of ICOS signal in colorectal cancer patients
Y Zhang, Y Luo, SL Qin, YF Mu, Y Qi, MH Yu… - …, 2016 - Taylor & Francis
The inducible T-cell co-stimulator (ICOS) belongs to the B7-CD28 immunoglobulin
superfamily, which is currently the subject of intense study due to great successes gained in …
superfamily, which is currently the subject of intense study due to great successes gained in …
[HTML][HTML] T regulatory cell markers in oral squamous cell carcinoma: Relationship with survival and tumor aggressiveness
G Moreira, LB Fulgêncio… - Oncology …, 2010 - spandidos-publications.com
Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an
important role in tumor-associated immune response. Of these, T regulatory (Treg) cells …
important role in tumor-associated immune response. Of these, T regulatory (Treg) cells …
Expression of ICOS on human melanoma-infiltrating CD4+ CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression
L Strauss, C Bergmann, MJ Szczepanski… - The Journal of …, 2008 - journals.aai.org
Objective: Interaction of ICOS with its ligand (ICOSL, B7-H2) promotes T cell responses. As
CD4+ CD25 high Foxp3+ naturally occurring T regulatory cells in melanoma patients …
CD4+ CD25 high Foxp3+ naturally occurring T regulatory cells in melanoma patients …
ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori
H Nagase, T Takeoka, S Urakawa… - … journal of cancer, 2017 - Wiley Online Library
Regulatory T cells (Tregs) have an immunosuppressive role in the tumor microenvironment.
Since effector Tregs (eTregs), which have highly suppressive functions, are located in a …
Since effector Tregs (eTregs), which have highly suppressive functions, are located in a …
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