Background: One of the major causes of failure in chemotherapy for patients with acute
lymphoblastic leukemia (ALL) is the acquisition of multidrug resistance (MDR). Predominant …

Resistance to chemotherapy is an obstacle to the successful treatment of oncohematological
malignances. Failure of therapeutic treatment may be due to the development of multidrug …

Chemotherapy failure remains a challenge when treating patients with acute myeloid
leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug …

Objectives: Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of
acute leukemias in adults. A high percentage of adult patients (ranging from 70 to 80%) …

Aim Multidrug resistance (MDR1) represents a major obstacle in the chemotherapeutic
treatment of acute leukemia (AL). Adenosine triphosphate ATP-binding cassette (ABCB5) …

Purpose In acute lymphoblastic leukemia (ALL), multidrug resistance is often mediated by
ATPase Binding Cassette (ABC) proteins, which principally involve ABCB1 (multidrug …

Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in
generating the MDR phenotype is controversial. With this in mind, this review compiled the …

Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different
degrees of differentiation. One of the known multidrug resistance mechanisms in acute …

Background Overexpression of ATP-binding cassette (ABC) drug transporters is a major
barrier in the success of cancer chemotherapy. One way to overcome overexpression of …

Background: A major issue in the treatment of acute myeloid leukemia (AML) is resistance to
chemotherapeutic drugs. Multidrug resistance can be caused by ATP-binding cassette …