SOX2 and ALDH1 as predictors of operable breast cancer

H Shima, G Kutomi, F Satomi, H Maeda… - Anticancer …, 2016 - ar.iiarjournals.org
Aim: Sex-determining region Y-box binding protein-2 (SOX2) and aldehyde dehydrogenase-
1 (ALDH1) are known cancer stem-cell markers, and represent candidate predictors for …

Increased SOX 2 expression in less differentiated breast carcinomas and their lymph node metastases

YH Huang, MH Luo, YB Ni, JYS Tsang… - …, 2014 - Wiley Online Library
Aims SOX 2 is a key regulatory gene in embryonic stem cells. Although it has been
implicated in cancer progression, its role in breast carcinoma is poorly understood. Materials …

The clinical and molecular characteristics of sex-determining region Y-box 2 and its prognostic value in breast cancer: a systematic meta-analysis

G Zhao, X Wang, L Qu, Z Zhu, J Hong, H Hou, Z Li… - Breast Care, 2021 - karger.com
Objective: Transcription factor SOX2 (sex-determining region Y-box 2) has a crucial role in
the maintenance of the stem cell state. However, current evidence regarding the role of …

SOX4 overexpression is a novel biomarker of malignant status and poor prognosis in breast cancer patients

GD Song, Y Sun, H Shen, W Li - Tumor Biology, 2015 - Springer
Sex-determining region Y-related high mobility group box 4 (SOX4) has been proven to
serve as a critical role in cancer development and progression. However, little is known …

[HTML][HTML] Clinicopathological significance of Sox2 expression in patients with breast cancer: a meta-analysis

Y Zheng, B Qin, F Li, S Xu, S Wang… - International Journal of …, 2015 - ncbi.nlm.nih.gov
Sex-determining region Y-box protein 2 (Sox2), an embryonic transcription factor located at
chromosome 3q26. 33, has been frequently demonstrated to be an important prognostic …

[HTML][HTML] Predictive value of stemness factor Sox2 in gastric cancer is associated with tumor location and stage

L Yang, JF Xu, Q Kang, AQ Li, P Jin, X Wang, YQ He… - PLoS …, 2017 - journals.plos.org
Cancer stem cells (CSCs) are thought to be the" root" of cancer. Although stemness-related
factors ALDH1A1 and Sox2 have been used as markers to identify gastric CSCs, the …

[HTML][HTML] Expression of SOX11 and HER2 and their association with recurrent breast cancer

FW Wang, X Ao, SM Fu - Translational Cancer Research, 2019 - ncbi.nlm.nih.gov
Background Recurrent breast cancer occurs as a result of divergent gene expression in
response to therapeutic intervention. A recent report showed that SOX11, an embryogenic …

Are embryonic stem cell markers and ALDH1A1 relevant in the context of breast cancer estrogen positivity?

NA Mousa, A Hussein, NM Elemam… - Cancer …, 2024 - Wiley Online Library
Background Embryonic pluripotency markers are recognized for their role in ER− BC
aggressiveness, but their significance in ER+ BC remains unclear. This study aims to …

Aldehyde dehydrogenase 1-related genes in triple-negative breast cancer investigated using network analysis

A Yamada, C Suzuki, H Shima, K Kida… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Aldehyde dehydrogenase 1 (ALDH1) is known as a breast cancer stem
cell (CSC) marker. This study aimed to identify genes associated with ALDH1. Materials and …

Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent

M Sjöström, L Hartman, G Honeth, D Grabau… - Journal of Clinical …, 2015 - jcp.bmj.com
Aims Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of
breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or …